Reactive oxygen species (ROS) and calcium (Ca2+) signalling are interconnected in the
perception and transmission of environmental signals that control plant growth, development …

Abstract Calcium (Ca 2+) signaling is critical for cell function and cell survival. Mitochondria
play a major role in regulating the intracellular Ca 2+ concentration ([Ca 2+] i). Mitochondrial …

Mitochondria are essential for proper cellular function through their critical roles in ATP
synthesis, reactive oxygen species production, calcium (Ca2+) buffering, and apoptotic …

Background Spatial compartmentalization of metabolic pathways within membrane-
separated organelles is key to the ability of eukaryotic cells to precisely regulate their …

Lysosomal calcium (Ca2+) release is critical to cell signaling and is mediated by well-known
lysosomal Ca2+ channels. Yet, how lysosomes refill their Ca2+ remains hitherto …

Mitochondrial dysfunction is linked to age-associated inflammation or inflammaging, but
underlying mechanisms are not understood. Analyses of 700 human blood transcriptomes …

Simple Summary Chemotherapy resistance is a common occurrence during cancer
treatment that cancer researchers are attempting to understand and overcome. Mitochondria …

Mitochondrial Ca 2+ uptake, mediated by the mitochondrial Ca 2+ uniporter, regulates
oxidative phosphorylation, apoptosis, and intracellular Ca 2+ signaling. Previous studies …

Pharmacological targeting of mitochondrial ion channels is emerging as a promising
approach to eliminate cancer cells; as most of these channels are differentially expressed …

Background Patients with metabolic syndrome (MetS) have an increased risk of atrial
fibrillation (AF). Impaired Ca2+ homeostasis and mitochondrial dysfunction have emerged …