Mechanism of action of ribosomally synthesized and post-translationally modified peptides

C Ongpipattanakul, EK Desormeaux… - Chemical …, 2022 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a natural
product class that has undergone significant expansion due to the rapid growth in genome …

Organic cation transporters in health and disease

H Koepsell, LC Daws - Pharmacological reviews, 2020 - Elsevier
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …

Hepatocellular carcinoma pathogenesis: from genes to environment

PA Farazi, RA DePinho - Nature Reviews Cancer, 2006 - nature.com
Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …

DNA microarray technology: devices, systems, and applications

MJ Heller - Annual review of biomedical engineering, 2002 - annualreviews.org
▪ Abstract In this review, recent advances in DNA microarray technology and their
applications are examined. The many varieties of DNA microarray or DNA chip devices and …

Molecular pathogenesis of human hepatocellular carcinoma

SS Thorgeirsson, JW Grisham - Nature genetics, 2002 - nature.com
Hepatocarcinogenesis is a slow process during which genomic changes progressively alter
the hepatocellular phenotype to produce cellular intermediates that evolve into …

[HTML][HTML] Functional genomics analysis of low concentration of ethanol in human hepatocellular carcinoma (HepG2) cells. Role of genes involved in transcriptional and …

F Castaneda, S Rosin-Steiner… - International journal of …, 2007 - ncbi.nlm.nih.gov
We previously found that ethanol at millimolar level (1 mM) activates the expression of
transcription factors with subsequent regulation of apoptotic genes in human hepatocellular …

Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA

K Panzitt, MMO Tschernatsch, C Guelly, T Moustafa… - Gastroenterology, 2007 - Elsevier
Background & Aims: Recent studies have highlighted the role of noncoding RNAs (ncRNAs)
in carcinogenesis, and suggested that this class of genes might be used as biomarkers in …

FOXM1: From cancer initiation to progression and treatment

CY Koo, KW Muir, EWF Lam - Biochimica et Biophysica Acta (BBA)-Gene …, 2012 - Elsevier
The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological
processes, including cell proliferation, cell cycle progression, cell differentiation, DNA …

[PDF][PDF] Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling

JS Lee, IS Chu, J Heo, DF Calvisi, Z Sun… - …, 2004 - Wiley Online Library
We analyzed global gene expression patterns of 91 human hepatocellular carcinomas
(HCCs) to define the molecular characteristics of the tumors and to test the prognostic value …

Predicting hepatitis B virus–positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning

QH Ye, LX Qin, M Forgues, P He, JW Kim, AC Peng… - Nature medicine, 2003 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human
malignancies. Its high mortality rate is mainly a result of intra-hepatic metastases. We …