Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …

Men and women exhibit differences in the development and progression of Alzheimer's
disease (AD). The factors underlying the sex differences in AD are not well understood. This …

Importance Mounting evidence suggests that sex differences exist in the pathologic
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

Studies have shown differences in specific cognitive ability domains and risk of Alzheimer's
disease between the men and women at later age. However it is important to know that sex …

JNPL3 transgenic mice expressing a mutant tau protein, which develop neurofibrillary
tangles and progressive motor disturbance, were crossed with Tg2576 transgenic mice …

The cause of Alzheimer's disease (AD) is closely related to the aggregation of a normal
protein, β-amyloid (Aβ), within the neocortex. Recently, evidence has been gathered to …

Introduction Our objective was to investigate the effect of sex on cognitive decline within the
context of amyloid β (Aβ) burden and apolipoprotein E genotype. Methods We analyzed sex …

In AD, an imbalance between Aβ production and removal drives elevated brain Aβ levels
and eventual amyloid plaque deposition. APP undergoes nonamyloidogenic processing via …