Aminoglycoside antibiotics target the ribosome and induce mistranslation, yet which
translation errors induce bacterial cell death is unclear. The analysis of cellular proteins by …

Objectives Widespread antimicrobial resistance often limits the availability of therapeutic
options to only a few last-resort drugs that are themselves challenged by emerging …

Objective The emergence of carbapenem-resistant and hypervirulent Klebsiella
pneumoniae (CR-hvKp) strains poses a significant public threat, and effective antimicrobial …

This paper presents a comprehensive review of the current literature, clinical trials, and
products approved for the delivery of antibiotics to the lungs. While there are many literature …

Background Apramycin is under development for human use as EBL-1003, a crystalline free
base of apramycin, in face of increasing incidence of multidrug-resistant bacteria. Both …

Aminoglycoside antibiotics are powerful bactericidal therapeutics that are often used in the
treatment of critical Gram-negative systemic infections. The emergence and global spread of …

Apramycin is a structurally unique member of the 2-deoxystreptamine class of
aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that …

Objectives: To evaluate the in vitro antibacterial, antibiofilm, and antivirulence activities of
apramycin, comparatively to tobramycin, against a set of P. aeruginosa from chronically …

An intramolecular hydrogen bond between the protonated equatorial 7'‐methylamino group
of apramycin and the vicinal axial 6'‐hydroxy group acidifies the 6'‐hydroxy group leading to …

Abstract Background The emergence of Neisseria gonorrhoeae resistant to all currently
available antimicrobial therapies poses a dire public health threat. New antimicrobial agents …