Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Voltage-gated sodium (Nav) channels initiate action potentials in most neurons, including
primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non …

KCNQ genes encode five Kv7 K+ channel subunits (Kv7. 1–Kv7. 5). Four of these (Kv7. 2–
Kv7. 5) are expressed in the nervous system. Kv7. 2 and Kv7. 3 are the principal molecular …

A cardinal feature of inflammation is heightened pain sensitivity at the site of the inflamed
tissue. This results from the local release by immune and injured cells of nociceptor …

Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

The ability to react to environmental change is crucial for the survival of an organism and an
essential prerequisite is the capacity to detect and respond to aversive stimuli. The …

The sensation of cold or heat depends on the activation of specific nerve endings in the skin.
This involves heat‐and cold‐sensitive excitatory transient receptor potential (TRP) channels …

The TREK‐1 channel is a temperature‐sensitive, osmosensitive and mechano‐gated K+
channel with a regulation by Gs and Gq coupled receptors. This paper demonstrates that …

Acid‐sensing ion channels (ASICs) are cationic channels activated by extracellular acidosis
that are expressed in both central and peripheral nervous systems. Although peripheral …