Cholesterol is an essential component of mammalian cell membranes and a precursor for
crucial signaling molecules. The brain contains the highest level of cholesterol in the body …

The first line of defense against viral infection of the host cell is the cellular lipid membrane,
which is also a crucial first site of contact for viruses. Lipids may sometimes be used as viral …

Current clinical interventions for stroke majorly involve thrombolysis or thrombectomy,
however, cessation of the progressive deleterious cellular cascades post-stroke and long …

To date, various agents and molecules have been developed to treat post-stroke
neuroinflammation; however, none of them are clinically successful. Post-stroke …

Background Pathophysiology plays a significant role in the scientific study of ischemic
stroke, and has attracted increasing interest from researchers in the field. However, a …

Statins have evident neuroprotective role in acute ischemic stroke (AIS). The pleiotropic
effect by which statin exerts neuroprotective effects, needs to be explored for considering it …

The management of acute ischemic stroke remains challenging due to its abrupt onset and
the narrow treatment window, resulting in high rates of disability and mortality. Combination …

The blood–brain barrier (BBB) is the most central component of the neurovascular unit
(NVU) and is crucial for the maintenance of the internal environment of the central nervous …

Cardiolipin (CL) is an essential phospholipid that supports the functions of mitochondrial
membrane transporters and oxidative phosphorylation complexes. Due to the high level of …

Ischemia-reperfusion injury (IRI) is a major cause of mortality and morbidity. Current
treatments for IRI have limited efficacy and novel therapeutic strategies are needed …