1, 3, 4-Thiadiazole: synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry

Y Hu, CY Li, XM Wang, YH Yang, HL Zhu - Chemical reviews, 2014 - ACS Publications
Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

1, 3, 4‐Thiadiazole and its derivatives: A review on recent progress in biological activities

AK Jain, S Sharma, A Vaidya… - Chemical biology & …, 2013 - Wiley Online Library
The 1, 3, 4‐thiadiazole nucleus is one of the most important and well‐known heterocyclic
nuclei, which is a common and integral feature of a variety of natural products and medicinal …

1, 3, 4-Thiadiazoles: A potent multi targeted pharmacological scaffold

S Haider, MS Alam, H Hamid - European journal of medicinal chemistry, 2015 - Elsevier
Despite a significant work on thiadiazoles, continuous efforts are still being made to identify
novel heterocyclic compounds with potent biological activities. This review may help the …

Antileishmanial drug discovery: Comprehensive review of the last 10 years

JN Sangshetti, FAK Khan, AA Kulkarni, R Arote… - Rsc Advances, 2015 - pubs.rsc.org
Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa
(trypanosomatids) from the genus Leishmania, has not received the attention it deserves …

Fruitful decade for antileishmanial compounds from 2002 to late 2011

H Hussain, A Al-Harrasi, A Al-Rawahi, IR Green… - Chemical …, 2014 - ACS Publications
Leishmaniasis, usually caused by the genus Leishmania, has not received the attention it
deserves and in recent times has developed into a major health problem worldwide. 1, 2 …

An overview of azoles targeting sterol 14α-demethylase for antileishmanial therapy

S Emami, P Tavangar, M Keighobadi - European journal of medicinal …, 2017 - Elsevier
The azole antifungal drugs are an important class of chemotherapeutic agents with broad-
spectrum of activity against yeasts and filamentous fungi, act in the ergosterol biosynthetic …

Thiadiazole inhibitors: a patent review

KM Dawood, TA Farghaly - Expert opinion on therapeutic patents, 2017 - Taylor & Francis
Introduction: Four isomeric structures of thiadiazole motifs have outstanding
pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is …

An update on small molecule strategies targeting leishmaniasis

S Kapil, PK Singh, OM Silakari - European journal of medicinal chemistry, 2018 - Elsevier
Leishmaniasis is an infectious disease caused by various species of protozoan parasite
known as Leishmania, which is transmitted to its mammalian host via bite of an infected …

Recent developments on synthesis strategies, SAR studies and biological activities of β-Carboline derivatives–an update

R Abinaya, S Srinath, S Soundarya, R Sridhar… - Journal of Molecular …, 2022 - Elsevier
The β-carboline skeleton is prevalent in a vast collection of naturally present alkaloids. Most
of these alkaloids and their derivatives have been found to show significant biological …