Reactive species are frequently formed after viral infections. Antioxidant defences, including
enzymatic and non-enzymatic components, protect against reactive species, but sometimes …

Proteins are oxidatively modified by a large number of reactive species including reactive
oxygen species, lipid peroxidation-derived aldehydes, and reducing sugars. Among …

The recent knowledge on mitochondria as the substantial source of reactive oxygen species,
namely superoxide and hydrogen peroxide efflux from mitochondria, is reviewed, as well as …

Hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, up‐regulates expression
of the β‐site APP cleaving enzyme (BACE‐1), an aspartyl protease responsible for the β …

For a decade or two, the hypothesis of causality of various disorders by reactive oxygen
species (ROS), due to their potentially harmful effect towards cellular constituents, is one of …

Although investigation of the toxicological and physiological actions of α/β-unsaturated 4-
hydroxyalkenals has made great progress over the last 2 decades, understanding of the …

The objective of this study was to determine the effects of aging and exercise training on
SIRT1 activity and to identify a pathway linking SIRT1 to antioxidant response and cell cycle …

In their reductionist approach in unraveling phenomena inside the cell, scientists in recent
times have focused attention to mitochondria. An organelle with peculiar evolutionary history …

During the past several years, major advances have been made in understanding how
reactive oxygen species (ROS) and nitrogen species (RNS) participate in signal …

Mitochondria have long been known to play a critical role in maintaining bioenergetic status
under physiological conditions. Our previous studies have shown that acute heat stress …