The immunopathogenesis of fibrosis in systemic sclerosis
M Brown, S O'Reilly - Clinical & Experimental Immunology, 2019 - academic.oup.com
Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …
The pathogenesis of systemic sclerosis
TR Katsumoto, ML Whitfield… - Annual Review of …, 2011 - annualreviews.org
Systemic sclerosis (SSc), also known as scleroderma, is a rare connective tissue disease
characterized by vascular and immune dysfunction, leading to fibrosis that can damage …
characterized by vascular and immune dysfunction, leading to fibrosis that can damage …
Abatacept in early diffuse cutaneous systemic sclerosis: results of a phase II investigator‐initiated, multicenter, double‐blind, randomized, placebo‐controlled trial
Objective T cells play a key role in the pathogenesis of early systemic sclerosis. This study
was undertaken to assess the safety and efficacy of abatacept in patients with diffuse …
was undertaken to assess the safety and efficacy of abatacept in patients with diffuse …
Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis
A Kuzumi, A Yoshizaki, KM Matsuda, H Kotani… - Nature …, 2021 - nature.com
Systemic sclerosis (SSc) is a chronic multisystem disorder characterized by fibrosis and
autoimmunity. Interleukin (IL)-31 has been implicated in fibrosis and T helper (Th) 2 immune …
autoimmunity. Interleukin (IL)-31 has been implicated in fibrosis and T helper (Th) 2 immune …
[HTML][HTML] Gastrointestinal manifestations of systemic sclerosis
IM McFarlane, MS Bhamra, A Kreps… - Rheumatology …, 2018 - ncbi.nlm.nih.gov
Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibroproliferative
alterations of the microvasculature leading to fibrosis and loss of function of the skin and …
alterations of the microvasculature leading to fibrosis and loss of function of the skin and …
Vasculopathy in scleroderma
Y Asano, S Sato - Seminars in immunopathology, 2015 - Springer
Systemic sclerosis (SSc) is a multisystem connective tissue disorder featured by vascular
injury and fibrosis of the skin and various internal organs with autoimmune background …
injury and fibrosis of the skin and various internal organs with autoimmune background …
Is CD69 an effective brake to control inflammatory diseases?
R González-Amaro, JR Cortés… - Trends in molecular …, 2013 - cell.com
Early studies described CD69 as a leukocyte activation marker, and suggested its
involvement in the activation of different leukocyte subsets as well as in the pathogenesis of …
involvement in the activation of different leukocyte subsets as well as in the pathogenesis of …
Systemic sclerosis
Y Asano - The Journal of dermatology, 2018 - Wiley Online Library
Systemic sclerosis (SS c) is a multisystem autoimmune disease characterized by
vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic …
vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic …
T cells in systemic sclerosis: a reappraisal
SSc is an autoimmune disease characterized by inflammation and extracellular matrix
deposition that ultimately leads to loss of organ function. T cells appear to play a prominent …
deposition that ultimately leads to loss of organ function. T cells appear to play a prominent …
[HTML][HTML] Tofacitinib blocks IFN-regulated biomarker genes in skin fibroblasts and keratinocytes in a systemic sclerosis trial
BACKGROUND Systemic sclerosis (SSc) is an autoimmune, connective tissue disease
characterized by vasculopathy and fibrosis of the skin and internal organs. METHODS We …
characterized by vasculopathy and fibrosis of the skin and internal organs. METHODS We …