Nanoparticle-based therapeutics are poised to become a leading delivery strategy for
cancer treatment because they potentially offer higher selectivity, reduced toxicity, longer …

Increasing evidence shows that the extracellular matrix (ECM) is an important regulator of
breast cancer (BC). The ECM comprises of highly variable and dynamic components …

Cells sense and respond to the surrounding microenvironment through binding of
membranous integrin to ligands such as the Arg-Gly-Asp (RGD) peptide. Previous studies …

The tumor microenvironment (TME) is cellular environment in addition to harboring
carcinoma cells, consists of different components (eg, blood vessels, immune cells …

The stability and dispersity of gold nanoparticles (AuNPs) against various biological,
physicochemical, and physiological transformations while retaining biocompatibility are …

Intratumoral drug delivery is an inherently appealing approach for concentrating toxic
chemotherapies at the site of action. This mode of administration is currently used in a …

An emerging concept is that cancers strongly depend on both internal and external signals
for growth and invasion. In this review, we will discuss pathological and physical changes in …

We report the development of novel tumor-targeted conjugated polymer nanoparticles
(CPNPs) carrying iron for chemodynamic therapy (CDT). Tumor cell killing proceeds through …

A novel fluorescence nanoprobe for the detection of matrix metalloproteinase 2 (MMP2) has
been developed by engineering the fluorescein isothiocyanate-labeled peptide onto the …

The first intermolecular ring-expansion cascade of azirines with alkynes for the synthesis of
pyridines, enabled by a copper/triethylamine catalytic system via simultaneous generation …