Applications, challenges, and outlook for PBPK modeling and simulation: a regulatory, industrial and academic perspective
W Lin, Y Chen, JD Unadkat, X Zhang, D Wu… - Pharmaceutical …, 2022 - Springer
Several regulatory guidances on the use of physiologically based pharmacokinetic (PBPK)
analyses and physiologically based biopharmaceutics model (s)(PBBM (s)) have been …
analyses and physiologically based biopharmaceutics model (s)(PBBM (s)) have been …
The role of uptake and efflux transporters in the disposition of glucuronide and sulfate conjugates
E Järvinen, F Deng, W Kiander, A Sinokki… - Frontiers in …, 2022 - frontiersin.org
Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The
resulting glucuronide and sulfate conjugates are generally considered inactive and safe …
resulting glucuronide and sulfate conjugates are generally considered inactive and safe …
Data-independent acquisition (DIA): an emerging proteomics technology for analysis of drug-metabolizing enzymes and transporters
Data-independent acquisition (DIA) proteomics is a recently-developed global mass
spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated …
spectrometry (MS)-based proteomics strategy. In a DIA method, precursor ions are isolated …
Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and …
Drug-drug interactions (DDIs) arising from the perturbation of drug metabolising enzyme
activities represent both a clinical problem and a potential economic loss for the …
activities represent both a clinical problem and a potential economic loss for the …
Quantitative investigation of irinotecan metabolism, transport, and gut microbiome activation
The anticancer drug irinotecan shows serious dose-limiting gastrointestinal toxicity
regardless of intravenous dosing. Although enzymes and transporters involved in irinotecan …
regardless of intravenous dosing. Although enzymes and transporters involved in irinotecan …
Co-Exposure of Phenanthrene and the cyp-Inducer 3-Methylchrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae
CE Donald, E Sørhus, P Perrichon… - Environmental …, 2023 - ACS Publications
Polycyclic aromatic hydrocarbons (PAHs) have frequently been suspected of governing
crude oil toxicity because of similar morphological defects in fish. However, PAH …
crude oil toxicity because of similar morphological defects in fish. However, PAH …
Cannabinoids and drug metabolizing enzymes: Potential for drug-drug interactions and implications for drug safety and efficacy
Introduction Cannabis is an increasingly popular recreational and medicinal drug in the
USA. While cannabis is still a Schedule 1 drug federally, many states have lifted the ban on …
USA. While cannabis is still a Schedule 1 drug federally, many states have lifted the ban on …
Pharmacogenetics of human sulfotransferases and impact of amino acid exchange on Phase II drug metabolism
Sulfotransferases (SULTs) are Phase II drug-metabolizing enzymes (DMEs) catalyzing the
sulfation of a variety of endogenous compounds, natural products, and drugs. Various drugs …
sulfation of a variety of endogenous compounds, natural products, and drugs. Various drugs …
Inhibition of UDP-glucuronosyltransferase enzymes by major cannabinoids and their metabolites
The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the
metabolism and detoxification of a wide range of endogenous and exogenous compounds …
metabolism and detoxification of a wide range of endogenous and exogenous compounds …
Human variability in carboxylesterases and carboxylesterase-related uncertainty factors for chemical risk assessment
Carboxylesterases (CES) are an important class of enzymes involved in the hydrolysis of a
range of chemicals and show large inter-individual variability in vitro. An extensive literature …
range of chemicals and show large inter-individual variability in vitro. An extensive literature …