Aromatic interactions play a vital role in chemistry and biology. As about 20% are aromatic in
nature, so the role of aromatic interactions become prominent in drug receptor interactions …

Serotonin (5-HT) receptors are part of the G protein-coupled and ligand-gated ion channel
families. 5-HT exerts its diverse actions by binding to cell surface receptors which can be …

A new silane-promoted nickel-catalyzed amination of aryl chlorides with 0.5 mol% of Ni
(acac) 2, 1 mol% of 3, 5, 6, 8-tetrabromo-1, 10-phenanthroline, and polymethylhydrosiloxane …

GPCRs are a family of transmembrane receptors that are profoundly linked to various
neurological disorders, among which is Parkinson's disease (PD). PD is the second most …

Introduction of a new drug to the market is a challenging and resource-consuming process.
Predictive models developed with the use of artificial intelligence could be the solution to the …

A series of novel 4-butyl-arylpiperazine-3-(1H-indol-3-yl) pyrrolidine-2, 5-dione derivatives
were synthesized and evaluated for their 5-HT 1A/D 2 receptor affinity and serotonin …

Despite its remarkable importance in the arena of drug design, serotonin 1A receptor (5-
HT1A) has been elusive to the X-ray crystallography community. This lack of direct structural …

Arylpiperazine derivatives are promising 5-hydroxytryptamine (5-HT) receptor ligands which
can inhibit serotonin reuptake effectively. In this work, some norm index descriptors were …

Clinical properties of atypical antipsychotics are based on their interaction with D2
dopamine receptor and serotonin 5‐HT1A and 5‐HT2A receptors. As a part of our research …

5-HT1A receptor antagonists have been employed to treat depression, but the lack of
structural information on this receptor hampers the design of specific and selective ligands …