Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses
immersed in aberrant communication circuits that facilitate tumor growth and dissemination …

Perineural invasion (PNI) can be found in a variety of malignant tumors. It is a sign of tumor
metastasis and invasion and portends the poor prognosis of patients. The pathological …

Nerves are important pathological elements of the microenvironment of tumors, including
those in pancreatic, colon and rectal, prostate, head and neck, and breast cancers. Recent …

Studies have reported the vital role of nerves in tumorigenesis and cancer progression.
Nerves infiltrate the tumor microenvironment thereby enhancing cancer growth and …

How tissues are maintained over a lifetime and repaired following injury are fundamental
questions in biology with a disruption to these processes underlying pathologies such as …

Perineural invasion (PNI), a pathologic feature defined as cancer cell invasion in, around,
and through nerves, is an indicator of poor prognosis and survival in prostate cancer (PC) …

Simple Summary Researchers have shown that tumor biomarkers and increased nerve
density are important clinical tools for determining cancer prognosis and developing …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and
pathogenic modifications to the peripheral nervous system that elevate metastatic capacity …