Forty years of research have established that the p53 tumor suppressor provides a major
barrier to neoplastic transformation and tumor progression by its unique ability to act as an …

Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

Emerging evidence revealed the significant roles of heat shock factor 1 (HSF1) in cancer
initiation, development, and progression, but there is no pan‐cancer analysis of HSF1. The …

Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its
propensity for early local and distant spread, affected patients possess extremely poor …

Proteomic instability is causally related to human diseases. In guarding proteome stability,
the heat shock factor 1 (HSF1)-mediated proteotoxic stress response plays a pivotal role …

There exists a phenomenon in aging research whereby early life stress can have positive
impacts on longevity. The mechanisms underlying these observations suggest a robust, long …

Mechanistic studies from cell culture and animal models have revealed critical roles for the
heat shock protein Hsp70 in cancer initiation and progression. Surprisingly, many effects of …

Tumour metastasis is the major adverse factor for recurrence and death in pancreatic cancer
(PC) patients. P53 mutations are considered to be the second most common type of …

Abstract Background Receptor tyrosine kinases (RTKs) are signaling enzymes responsible
for the transfer of Adenosine triphosphate (ATP) γ-phosphate to the tyrosine residues …

The heat shock protein (Hsps) superfamily, also known as molecular chaperones, are highly
conserved and present in all living organisms and play vital roles in protein fate. The …