Wnt signaling plays a crucial role in embryonic development and homeostasis maintenance.
Delicate and sensitive fine-tuning of Wnt signaling based on the proper timings and …

Post-translational modifications (PTMs) alter protein conformation by covalently attaching
functional groups to substrates, influencing their biological activity, mechanisms of action …

The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem
cells residing at the crypt bottom. Paneth cells form a major element of the niche …

Current methods for the macrocyclization of phage-displayed peptides often rely on small
molecule linkers that nonspecifically react with targeted amino acid residues. To expand tool …

Cancer cells depend on specific oncogenic pathways or present a genetic alteration that
leads to a particular disturbance. Still, personalized and targeted biological therapy remains …

Background: Colorectal cancer, a prevalent gastrointestinal carcinoma, has a high risk for
recurrence when locally advanced and remains lethal when in an advanced stage …

Wnt signaling is essential for both the development and homeostasis of diverse cellular
lineages, including hematopoietic stem cells. Organism-wide, Wnt signals are tightly …

Background and Aims Necrotizing enterocolitis is a severe gastrointestinal complication of
prematurity. Using small intestinal organoids derived from fetal tissue of a gestational age …

Frizzled (FZD) proteins are the principal receptors of the Wnt signaling pathway. However,
whether Wnt ligands induce FZD endocytosis and degradation remains elusive. The …

The Wnt signaling pathway is critical in the onset and progression of gastrointestinal (GI)
cancers. Anomalies in this pathway, often stemming from mutations in critical components …