Fungal metabolites are worthily taken into account as a pool of synthetically interesting and
remarkably important new lead compounds for medical, agricultural, and chemical …

BACKGROUND HIV-1–infected CD4+ T cells contribute to latent reservoir persistence by
proliferating while avoiding immune recognition. Integration features of intact proviruses in …

HIV-1 persists in infected individuals despite years of antiretroviral therapy (ART), due to the
formation of a stable and long-lived latent viral reservoir. Early ART can reduce the latent …

Infections with the human immunodeficiency virus type 1 (HIV-1) are incurable due the long-
lasting, latent viral reservoir. The shock-and-kill cure approach aims to activate latent …

To date, an affordable, effective treatment for an HIV-1 cure remains only a concept with
most “latency reversal” agents (LRAs) lacking specificity for the latent HIV-1 reservoir and …

T-cell-mediated immune responses play indispensable roles in the defense against
infectious pathogens including human immunodeficiency virus type 1 (HIV-1) which can …

Worldwide, almost 40 million people are currently living with HIV-1. The implementation of
cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently …

With nearly 38 million of people worldwide living with HIV-1 and no definitive cure available
after almost 40 years of research, AIDS is still a major global public health issue. Modern …

Among people living with human immunodeficiency virus type 1 (HIV-1), the long-term
persistence of a population of cells carrying transcriptionally silent integrated viral DNA …

Definitive cure of HIV-1 infected patients is limited by the persistence of viral reservoirs
under cART, where the interruption of the latter usually precipitates a viral rebound. Main …