The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

Two decades of studies in multiple model organisms have established the Hippo pathway
as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Angiogenesis is a multistep process that requires coordinated migration, proliferation, and
junction formation of vascular endothelial cells (ECs) to form new vessel branches in …

The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …

Control of cell number is crucial in animal development and tissue homeostasis, and its
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …

Studies over the past 20 years have defined the Hippo signaling pathway as a major
regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have …

The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and
Lats) and downstream transcription coactivators (YAP and TAZ), plays a key role in tissue …

First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of
organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor …

Precise control of organ size is crucial during animal development and regeneration. In
Drosophila and mammals, studies over the past decade have uncovered a critical role for …