A generalized method for analyzing the effects of multiple drugs and for determining
summation, synergism and antagonism has been proposed. The derived, generalized …

This brief perspective article focuses on the most common errors and pitfalls, as well as the
do's and don'ts in drug combination studies, in terms of experimental design, data …

Multidrug-resistant bacteria are an increasingly serious threat to human and animal health.
However, novel drugs that can manage infections by multidrug-resistant bacteria have …

Drugs designed to act against individual molecular targets cannot usually combat multigenic
diseases such as cancer, or diseases that affect multiple tissues or cell types such as …

To enhance therapeutic efficacy and reduce adverse effects, practitioners of traditional
Chinese medicine (TCM) prescribe a combination of plant species/minerals, called …

A simple, general and novel method for the quantitative analysis of combined drug effects is
presented. The procedure determines if the drug combinations are additive, synergistic or …

Drug combination discovery depends on reliable synergy metrics but no consensus exists
on the correct synergy criterion to characterize combined interactions. The fragmented state …

Combinatorial control of biological processes, in which redundancy and multifunctionality
are the norm, fundamentally limits the therapeutic index that can be achieved by even the …

Nearly four generations of investigators have studied combined drug effects. Their methods
of generating and analyzing data have changed dramatically over the years but the basic …

Background: Many cancer patients in phase I clinical trials are treated at doses of
chemotherapeutic agents that are below the biologically active level, thus reducing their …