The expression of DNA topoisomerase II α and β genes was studied in murine normal
tissues. Northern blot analysis using probes specific for the two genes showed that the …

Hepatocellular carcinoma and cholangiocarcinoma are the two most important primary
malignancies of the liver. These are among the tumours with the lowest response to …

Techniques for measuring DNA double strand breaks in mammalian cells are being used
increasingly by reseachers studying both physiological processes, such as recombination …

Taxotere (RP 56976, NSC 628503), an analog of taxol, is an inhibitor of depolymerisation of
microtubules and is currently in Phase I clinical trials. Comparisons of the cytotoxicities of …

Patterns of drug sensitivities in relation to topoisomerase II gene expression and activity
were studied in eight human lung cancer cell lines not selected in vitro for drug resistance …

Salvicine, a structurally modified diterpenoid quinone derived from Salvia prionitis, is a novel
anticancer drug candidate. The compound has significant in vitro and in vivo activity against …

Effective anticancer agents, such as epipodophyllotoxins and anthracyclines, exert their
antitumor activity through stabilization of cleavable topoisomerase II/DNA complexes, which …

From the roots of Salvia prionitis a new tricyclic diterpene, saprirearine (1), a new anhydride-
type compound, saprionide (2), a new 7, 8-seco-abietane diterpene derivative, 7, 8-seco …

The cytotoxic activity of mitoxantrone and related anthracenediones has been ascribed to
the ability of these cornpounds to interfere with DNA topoisomerase II function, result-ing in …

S16020-2 is a new olivacine derivative which has recently shown a marked antitumor
activity in various experimental models. This study was undertaken in order to measure the …