DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …

The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder with variable clinical
phenotypes that correlate with the type of mutations in the WAS protein (WASP) gene …

RNA/DNA hybrids form when RNA hybridizes with its template DNA generating a three-
stranded structure known as the R-loop. Knowledge of how they form and resolve, as well as …

Non-canonical secondary structures (NCSs) are alternative nucleic acid structures that differ
from the canonical B-DNA conformation. NCSs often occur in repetitive DNA sequences and …

Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR)
causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a …

The most stable structure of DNA is the canonical right-handed double helix termed B DNA.
However, certain environments and sequence motifs favor alternative conformations, termed …

Accurate genome replication is essential for all life and a key mechanism of disease
prevention, underpinned by the ability of cells to respond to replicative stress (RS) and …

Immunoactinopathies caused by mutations in actin‐related proteins are a growing group of
inborn errors of immunity (IEI). Immunoactinopathies are caused by a dysregulated actin …

Reversion mosaicism has been reported in an increasing number of genetic disorders
including primary immunodeficiency diseases. Several mechanisms can mediate somatic …

The diverse functions of WASP, the deficiency of which causes Wiskott-Aldrich syndrome
(WAS), remain poorly defined. We generated three isogenic WAS models using patient …