Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused
heterocyclic compound with a wide range of pharmacological prospective such as …

Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Quinoline is an efficient scaffold for anticancer drug development as its derivatives have
shown potent results through several mechanisms like growth regulators through “apoptosis …

Quinoline is one of the most important and versatile nitrogen heterocycles embodied in
several biologically active molecules. Within the numerous quinolines developed as …

Based on the biologically active heterocycle quinoline, a series (18a-p) of quinoline
hydrazone analogues were prepared, starting from 6-bromo/6-chloro-2-methyl-quinolin-4-yl …

The Povarov multicomponent reaction consists on the condensation of an aniline, an
aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity …

Catalytic asymmetric Povarov protocols have undergone an explosive growth, especially in
the last ten years, since the first example was published in 1996. The use of chiral Lewis and …

The construction of an all‐in‐one catalyst, in which the photosensitizer and the transition
metal site are close to each other, is important for improving the efficiency of …

In our attempt to develop potential anticancer agents targeting Topoisomerase I (TOP1), two
novel series of 4-alkoxy-2-arylquinolines 14a-p and 19a-c were designed and synthesized …