ATP-binding cassette (ABC) drug transporters in the developing blood–brain barrier: role in fetal brain protection

ME Eng, GE Imperio, E Bloise, SG Matthews - Cellular and Molecular Life …, 2022 - Springer
The blood–brain barrier (BBB) provides essential neuroprotection from environmental toxins
and xenobiotics, through high expression of drug efflux transporters in endothelial cells of …

Current status, challenges and perspectives in the development of vaccines against yellow fever, dengue, Zika and chikungunya viruses

JVJ Silva Jr, TRR Lopes, EF de Oliveira-Filho… - Acta tropica, 2018 - Elsevier
Emerging and re-emerging viral infections transmitted by insect vectors (arthopode-borne
viruses, arbovirus) are a serious threat to global public health. Among them, yellow fever …

SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus

E Branche, YT Wang, KM Viramontes… - Nature …, 2022 - nature.com
The emergence of Zika virus (ZIKV) as a global health threat has highlighted the unmet need
for ZIKV-specific vaccines and antiviral treatments. ZIKV infects dendritic cells (DC), which …

Zika virus infects, activates, and crosses brain microvascular endothelial cells, without barrier disruption

MP Papa, LM Meuren, SVA Coelho… - Frontiers in …, 2017 - frontiersin.org
Zika virus (ZIKV) has been associated to central nervous system (CNS) harm, and virus was
detected in the brain and cerebrospinal fluids of microcephaly and meningoencephalitis …

Identification of novel natural products as effective and broad-spectrum anti-Zika virus inhibitors

Y Gao, W Tai, N Wang, X Li, S Jiang, AK Debnath, L Du… - Viruses, 2019 - mdpi.com
Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome,
which includes microcephaly and other neurological malformations. No therapeutic agents …

Recent progresses and remaining challenges for the detection of Zika virus

X Zhang, G Li, G Chen, N Zhu, D Wu… - Medicinal Research …, 2021 - Wiley Online Library
Zika virus (ZIKV) has emerged as a particularly notorious mosquito‐borne flavivirus, which
can lead to a devastating congenital syndrome in the fetuses of pregnant mothers (eg …

Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses

W Tai, L He, Y Wang, S Sun, G Zhao… - Emerging microbes & …, 2018 - Taylor & Francis
Zika virus (ZIKV) infection remains a serious health threat due to its close association with
congenital Zika syndrome (CZS), which includes microcephaly and other severe birth …

Rational design of Zika virus subunit vaccine with enhanced efficacy

W Tai, J Chen, G Zhao, Q Geng, L He, Y Chen… - Journal of …, 2019 - Am Soc Microbiol
Zika virus (ZIKV) infection in pregnant women can lead to fetal deaths and malformations.
We have previously reported that ZIKV envelope protein domain III (EDIII) is a subunit …

Prevalence and clinical profile of microcephaly in South America pre-Zika, 2005-14: prevalence and case-control study

IM Orioli, H Dolk, JS Lopez-Camelo, D Mattos… - bmj, 2017 - bmj.com
Objective To describe the prevalence and clinical spectrum of microcephaly in South
America for the period 2005-14, before the start of the Zika epidemic in 2015, as a baseline …

Ocular abnormalities in congenital Zika syndrome: a case report, and review of the literature

JG Guevara, S Agarwal-Sinha - Journal of medical case reports, 2018 - Springer
Background As the number of children with Zika virus-related complications grows, the long-
term developmental trajectory and its effects on families are unknown. We present the first …