The incidence of acute pancreatitis continues to increase worldwide, and it is one of the
most common gastrointestinal causes for hospital admission in the USA. In the past decade …

Developments in managing CF continue to drive dramatic improvements in survival. As
newborn screening rolls-out across Europe, CF centres are increasingly caring for cohorts of …

Importance Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the
pancreas with a prevalence of 42 to 73 per 100 000 adults in the United States …

Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis,
pancreatic genetics has made rapid progress. The identification of mutations in genes …

Salt and fluid absorption and secretion are two processes that are fundamental to epithelial
function and whole body fluid homeostasis, and as such are tightly regulated in epithelial …

Chronic pancreatitis is a multifactorial, fibroinflammatory syndrome in which repetitive
episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting …

Genetic investigations have provided unique insight into the mechanism of chronic
pancreatitis in humans and firmly established that uncontrolled trypsin activity is a central …

Genetic defects in cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene
cause CF. Infants with CFTR mutations show a peribronchial neutrophil infiltration prior to …

Cystic fibrosis (CF) is the most common genetic disorder that causes a significant damage in
secretory epithelial cells due to the defective ion flux across the cystic fibrosis …

Background Chronic pancreatitis (CP) is a complex inflammatory disease with remarkably
impaired quality of life and permanent damage of the pancreas. This paper is part of the …