Nowadays, the pathophysiology of several central nervous system (CNS) disorders is still
poorly understood, making difficult the identification of efficient treatments. CNS damages …

An increasing interest in patient-specific disease modeling of neuropsychiatric disorders
with multifactorial etiology has been witnessed by researchers worldwide [1]. Bipolar …

The canonical Wnt signaling pathway plays a vital role in the developmental processes of
the Central Nervous System throughout both prenatal and postnatal stages, as well as in …

Background: Induced pluripotent stem cell (iPSC) based neuronal differentiation is valuable
for studying neuropsychiatric disorders and pharmacological mechanisms at the cellular …

Impaired neuroplasticity in neurons endowed in limbic circuits is considered a hallmark of
chronic stress and depression. The reasons for this impairment are still partially unclear, but …

Abstract Elevated interleukin (IL-) 6 levels during prenatal development have been linked to
increased risk for neurodevelopmental disorders (NDD) in the offspring, but the mechanism …

Since their discovery, induced pluripotent stem cells (iPSCs) have paved a new path for
regenerative medicine and the development of novel strategies for treating diseases …

Human pluripotent stem cells (hPSCs) have significant potential for disease modeling and
cell therapies. However, their clinical applicability is limited due to the need for undefined …

Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder
characterised by inattention, hyperactivity, and impulsivity, significantly impacting life quality …

As a highly prevalent neurodevelopmental disorder, attention-deficit hyperactivity disorder
(ADHD) mostly affects children and adolescents across the globe, and it is regarded as a …