Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments
M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …
astrocytes participate in several pathophysiological processes including neuroinflammation …
[HTML][HTML] Alzheimer's disease, obesity, and type 2 diabetes: focus on common neuroglial dysfunctions (critical review and new data on human brain and models)
A Toledano, A Rodríguez-Casado, MI Älvarez… - Brain Sciences, 2024 - mdpi.com
Background/Objectives. Obesity, type 2 diabetes (T2D), and Alzheimer's disease (AD) are
pathologies that affect millions of people worldwide. They have no effective therapy and are …
pathologies that affect millions of people worldwide. They have no effective therapy and are …
Activation of PPARα exhibits therapeutic efficacy in a mouse model of juvenile neuronal ceroid lipofuscinosis
Juvenile neuronal ceroid lipofuscinosis (JNCL) is a fatal inherited neurodegenerative
disease of children that occurs because of defective function of the lysosomal membrane …
disease of children that occurs because of defective function of the lysosomal membrane …
Treadmill workout activates PPARα in the hippocampus to upregulate ADAM10, decrease plaques and improve cognitive functions in 5XFAD mouse model of …
Although liver is rich in peroxisome proliferator-activated receptor α (PPARα), recently we
have described the presence of PPARα in hippocampus where it is involved in non …
have described the presence of PPARα in hippocampus where it is involved in non …
Deciphering Alzheimer's disease: Predicting new therapeutic strategies via improved understanding of biology and pathogenesis
R Khoury, GT Grossberg - Expert opinion on therapeutic targets, 2020 - Taylor & Francis
Introduction There is no cure for Alzheimer's disease (AD). One explanation may pertain to
the need to intervene as early as possible upstream from the accumulation of β-amyloid …
the need to intervene as early as possible upstream from the accumulation of β-amyloid …
Therapeutic efficacy of cinnamein, a component of balsam of Tolu/Peru, in controlled cortical impact mouse model of TBI
Traumatic brain injury (TBI) remains a major health concern which causes long-term
neurological disability particularly in war veterans, athletes and young adults. In spite of …
neurological disability particularly in war veterans, athletes and young adults. In spite of …
Upregulation of IL-1 receptor antagonist by aspirin in glial cells via peroxisome proliferator-activated receptor-alpha
Background: Neuroinflammation is a recognized aspect of Alzheimer's disease (AD) and
other neurological illnesses. Interleukin 1 receptor antagonist (IL-1Ra) is an anti …
other neurological illnesses. Interleukin 1 receptor antagonist (IL-1Ra) is an anti …
[HTML][HTML] Dual antiplatelet therapy improves functional recovery and inhibits inflammation after cerebral ischemia/reperfusion injury
W Dong, X Liu, W Liu, C Wang, S Zhao… - Annals of …, 2022 - ncbi.nlm.nih.gov
Background Dual antiplatelet therapy with aspirin and clopidogrel (ASA+ CPG) during the
first 21 days has been shown to reduce the risk of major ischemic events in patients with …
first 21 days has been shown to reduce the risk of major ischemic events in patients with …
Cytokines in Neurodegenerative Disorders
K Pahan - Neuroimmune Pharmacology and Therapeutics, 2024 - Springer
The pathogenesis of different neuroinflammatory and neurodegenerative diseases like
multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, and …
multiple sclerosis, Parkinson's disease, Alzheimer's disease, Huntington's disease, and …
Impaired brain equanimity and neurogenesis in the diet-induced overweight mouse: a preventive role by syringic acid treatment
Objectives In this study mice were fed a high-fat diet for 12 weeks to establish diet-induced
obesity and syringic acid (SA) was assessed for anti-obese, neuroprotective, and …
obesity and syringic acid (SA) was assessed for anti-obese, neuroprotective, and …