[HTML][HTML] Detection of tumor NTRK gene fusions to identify patients who may benefit from tyrosine kinase (TRK) inhibitor therapy
SJ Hsiao, A Zehir, AN Sireci, DL Aisner - The Journal of Molecular …, 2019 - Elsevier
Chromosomal rearrangements involving the NTRK1, NTRK2, and NTRK3 genes (NTRK
genes), which encode the high-affinity nerve growth factor receptor (TRKA), brain-derived …
genes), which encode the high-affinity nerve growth factor receptor (TRKA), brain-derived …
[HTML][HTML] Genomic and molecular landscape of DNA damage repair deficiency across the cancer genome atlas
TA Knijnenburg, L Wang, MT Zimmermann… - Cell reports, 2018 - cell.com
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view …
response. We systematically analyzed somatic alterations to provide a comprehensive view …
[HTML][HTML] Genomic basis for RNA alterations in cancer
PCAWG Transcriptome Core Group Calabrese Claudia … - Nature, 2020 - nature.com
Transcript alterations often result from somatic changes in cancer genomes. Various forms of
RNA alterations have been described in cancer, including overexpression, altered splicing …
RNA alterations have been described in cancer, including overexpression, altered splicing …
Defining the condensate landscape of fusion oncoproteins
Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
Driver fusions and their implications in the development and treatment of human cancers
Q Gao, WW Liang, SM Foltz, G Mutharasu… - Cell reports, 2018 - cell.com
Gene fusions represent an important class of somatic alterations in cancer. We
systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple …
systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple …
Clinically relevant fusion oncogenes: Detection and practical implications
M Sorokin, E Rabushko… - Therapeutic …, 2022 - journals.sagepub.com
Mechanistically, chimeric genes result from DNA rearrangements and include parts of
preexisting normal genes combined at the genomic junction site. Some rearranged genes …
preexisting normal genes combined at the genomic junction site. Some rearranged genes …
TumorFusions: an integrative resource for cancer-associated transcript fusions
Gene fusion represents a class of molecular aberrations in cancer and has been exploited
for therapeutic purposes. In this paper we describe TumorFusions, a data portal that …
for therapeutic purposes. In this paper we describe TumorFusions, a data portal that …
ChimerDB 4.0: an updated and expanded database of fusion genes
Fusion genes represent an important class of biomarkers and therapeutic targets in cancer.
ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep …
ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep …
INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases
R Beekhof, C van Alphen, AA Henneman… - Molecular systems …, 2019 - embopress.org
Identifying hyperactive kinases in cancer is crucial for individualized treatment with specific
inhibitors. Kinase activity can be discerned from global protein phosphorylation profiles …
inhibitors. Kinase activity can be discerned from global protein phosphorylation profiles …
Cell-free multi-omics analysis reveals potential biomarkers in gastrointestinal cancer patients' blood
During cancer progression, tumorigenic and immune signals are spread through circulating
molecules, such as cell-free DNA (cfDNA) and cell-free RNA (cfRNA) in the blood. So far …
molecules, such as cell-free DNA (cfDNA) and cell-free RNA (cfRNA) in the blood. So far …