Lipid-based nanoparticle technologies for liver targeting

R Böttger, G Pauli, PH Chao, NAL Fayez… - Advanced drug delivery …, 2020 - Elsevier
Liver diseases such as hepatitis, cirrhosis, and hepatocellular carcinoma are global health
problems accounting for approximately 800 million cases and over 2 million deaths per year …

Nanoparticles for the treatment of liver fibrosis

S Poilil Surendran, R George Thomas… - International journal …, 2017 - Taylor & Francis
Chronic liver diseases represent a global health problem due to their high prevalence
worldwide and the limited available curative treatment options. They can result from various …

[HTML][HTML] Macrophage MerTK promotes liver fibrosis in nonalcoholic steatohepatitis

B Cai, P Dongiovanni, KE Corey, X Wang… - Cell metabolism, 2020 - cell.com
Nonalcoholic steatohepatitis (NASH) is emerging as a leading cause of chronic liver
disease. However, therapeutic options are limited by incomplete understanding of the …

Selenium nanoparticles overcomes sorafenib resistance in thioacetamide induced hepatocellular carcinoma in rats by modulation of mTOR, NF-κB pathways and …

TM Al-Noshokaty, NM Mesbah, DM Abo-Elmatty… - Life Sciences, 2022 - Elsevier
Aims The first-line treatment for advanced hepatocellular carcinoma (HCC) is the
multikinase inhibitor sorafenib (SOR). Sofafenib resistance is linked to protein kinase …

Diagnostic imaging and therapeutic application of nanoparticles targeting the liver

H Wang, CA Thorling, X Liang, KR Bridle… - Journal of Materials …, 2015 - pubs.rsc.org
Liver diseases, particularly viral hepatitis, cirrhosis and hepatocellular carcinoma, are
common in clinical practice with high morbidity and mortality worldwide. Many substances …

[HTML][HTML] Therapeutic targeting of liver inflammation and fibrosis by nanomedicine

M Bartneck, KT Warzecha, F Tacke - Hepatobiliary surgery and …, 2014 - ncbi.nlm.nih.gov
Nanomedicine constitutes the emerging field of medical applications for nanotechnology
such as nanomaterial-based drug delivery systems. This technology may hold exceptional …

Extracellular matrix-penetrating nanodrill micelles for liver fibrosis therapy

QQ Fan, CL Zhang, JB Qiao, PF Cui, L Xing, YK Oh… - Biomaterials, 2020 - Elsevier
As hepatic stellate cells (HSCs) are essential for hepatic fibrogenesis, HSCs targeted nano-
drug delivery system is a research hotspot in liver fibrosis therapy. However, the excessive …

Cellular distribution of injected PLGA-nanoparticles in the liver

JK Park, T Utsumi, YE Seo, Y Deng, A Satoh… - … , Biology and Medicine, 2016 - Elsevier
The cellular fate of nanoparticles in the liver is not fully understood. Because the
effectiveness and safety of nanoparticles in liver therapy depends on targeting nanoparticles …

Bioinspired nanocomposites: applications in disease diagnosis and treatment

S Mishra, S Sharma, MN Javed… - Pharmaceutical …, 2019 - ingentaconnect.com
Recent advancement in the field of synthesis and application of nanomaterials provided
holistic approach for both diagnosis as well as treatment of diseases. Briefly, three …

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State‐of‐the‐Art Review

SA Moosavian, T Sathyapalan… - Bioinorganic …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to
end‐stage liver disease needing a liver transplant. Many pharmacological approaches are …