Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

Cardiovascular diseases are the number one cause of death worldwide and greatly impact
quality of life and medical costs. Enormous effort has been made in research to obtain new …

Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also
over larger genomic regions. In most human tissues, the vast majority of the genome is …

ABSTRACT Vitamin B-12 deficiency (< 148 pmol/L) is associated with adverse maternal and
neonatal outcomes, including developmental anomalies, spontaneous abortions …

MicroRNAs are a class of noncoding small RNAs that regulate the expression of nearly 30%
of all the human genes and participate in all fundamental cell processes. Genome-wide …

Potential adverse effects of excess maternal folic acid supplementation on a vegetarian
population deficient in vitamin B12 are poorly understood. We have previously shown in a …

Context: Placental angiogenesis contributes to the pathogenesis of preeclampsia (PE) that
affects 5–8% of all human pregnancies. MicroRNA (miRNA) are a class of noncoding 21-to …

Background Changes in imprinted gene dosage in the placenta may compromise the
prenatal control of nutritional resources. Indeed monoallelic behaviour and sensitivity to …

Males and females responses to gestational overnutrition set the stage for subsequent sex-
specific differences in adult onset non communicable diseases. Placenta, as a widely …

The human pan-tissue epigenetic clock is widely used for estimating age across the entire
lifespan, but it does not lend itself well to estimating gestational age (GA) based on placental …