Multiscale cancer modeling
Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC
A Kalikaki, A Koutsopoulos, M Trypaki… - British journal of …, 2008 - nature.com
In non-small-cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) and K-RAS
mutations of the primary tumour are associated with responsiveness and resistance to …
mutations of the primary tumour are associated with responsiveness and resistance to …
Quantitative modeling perspectives on the ErbB system of cell regulatory processes
MJ Lazzara, DA Lauffenburger - Experimental cell research, 2009 - Elsevier
The complexities of the processes involved in ErbB-mediated regulation of cellular
phenotype are broadly appreciated, so much so that it might be reasonably argued that this …
phenotype are broadly appreciated, so much so that it might be reasonably argued that this …
Quantitative prediction of fold resistance for inhibitors of EGFR
Clinical use of ATP-competitive inhibitors of the epidermal growth factor receptor (EGFR)
kinase domain can lead to an acquired drug resistant mutant L858R&T790M which …
kinase domain can lead to an acquired drug resistant mutant L858R&T790M which …
An integrated network representation of multiple cancer-specific data for graph-based machine learning
Genomic profiles of cancer cells provide valuable information on genetic alterations in
cancer. Several recent studies employed these data to predict the response of cancer cell …
cancer. Several recent studies employed these data to predict the response of cancer cell …
Ectodomain orientation, conformational plasticity and oligomerization of ErbB1 receptors investigated by molecular dynamics
J Kästner, HH Loeffler, SK Roberts… - Journal of structural …, 2009 - Elsevier
Epidermal growth factor receptor (EGFR; ErbB1, HER1 in humans) is a receptor tyrosine
kinase triggering signals across the plasma membranes of cells to determine cell fate. We …
kinase triggering signals across the plasma membranes of cells to determine cell fate. We …
Multi-scale, multi-resolution brain cancer modeling
L Zhang, LL Chen, TS Deisboeck - Mathematics and computers in …, 2009 - Elsevier
In advancing discrete-based computational cancer models towards clinical applications, one
faces the dilemma of how to deal with an ever growing amount of biomedical data that ought …
faces the dilemma of how to deal with an ever growing amount of biomedical data that ought …
A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptortyrosine kinase …
SE Telesco, AJ Shih, F Jia, R Radhakrishnan - Molecular BioSystems, 2011 - pubs.rsc.org
Multiscale modeling provides a powerful and quantitative platform for investigating the
complexity inherent in intracellular signaling pathways and rationalizing the effects of …
complexity inherent in intracellular signaling pathways and rationalizing the effects of …
[HTML][HTML] Mathematical modeling of therapeutic neural stem cell migration in mouse brain with and without brain tumors
J Gomez, N Holmes, A Hansen… - Mathematical …, 2022 - ncbi.nlm.nih.gov
Neural stem cells (NSCs) offer a potential solution to treating brain tumors. This is because
NSCs can circumvent the blood-brain barrier and migrate to areas of damage in the central …
NSCs can circumvent the blood-brain barrier and migrate to areas of damage in the central …
A water-based mechanism of specificity and resistance for lapatinib with ErbB family kinases
Y Huang, RC Rizzo - Biochemistry, 2012 - ACS Publications
The dual kinase inhibitor lapatinib has a high affinity for EGFR and HER2 but a weak affinity
for ErbB4, although the factors driving specificity for these highly homologous members of …
for ErbB4, although the factors driving specificity for these highly homologous members of …