New trends in the quality control of enantiomeric drugs: quality by design-compliant development of chiral capillary electrophoresis methods

S Orlandini, G Hancu, ZI Szabó, A Modroiu, LA Papp… - Molecules, 2022 - mdpi.com
Capillary electrophoresis (CE) is a potent method for analyzing chiral substances and is
commonly used in the enantioseparation and chiral purity control of pharmaceuticals from …

Recent development of chiral ionic liquids for enantioseparation in liquid chromatography and capillary electrophoresis: a review

H Liu, J Chen, M Chen, J Wang, H Qiu - Analytica Chimica Acta, 2023 - Elsevier
Ionic liquids (ILs), which are salts in a molten state below 100° C, have become a hot topic of
research in various fields because of their negligible vapour pressure, high thermal stability …

State-of-the-art extraction and separation of enantiomers through the application of alternative solvents

PY Quintas, EF Fiorentini, M Llaver… - TrAC Trends in …, 2022 - Elsevier
Enantiomeric separation is an increasing research area, as well as the application of
alternative solvents replacing classic volatile, flammable and toxic organic solvents. Among …

Functional materials in chiral capillary electrophoresis

Q Zhang, S Xue, A Li, S Ren - Coordination Chemistry Reviews, 2021 - Elsevier
Researchers in the field of chiral science have been endeavoring to develop high-
performance analytical methods for enantioseparations. The inherent flexibility of capillary …

A cooperation tale of biomolecules and nanomaterials in nanoscale chiral sensing and separation

T Hong, W Zhou, S Tan, Z Cai - Nanoscale Horizons, 2023 - pubs.rsc.org
The cooperation relation between biomolecules and nanomaterials makes up a beautiful
tale about nanoscale chiral sensing and separation. Biomolecules are considered a …

Chiral capillary electrokinetic chromatography: principle and applications, detection and identification, design of experiment, and exploration of chiral recognition …

S El Deeb, CF Silva, CSN Junior, RS Hanafi… - Molecules, 2021 - mdpi.com
This work reviews the literature of chiral capillary electrokinetic chromatography from
January 2016 to March 2021. This is done to explore the state-of-the-art approach and …

Recent advances in chiral analysis of proteins and peptides

M Morvan, I Mikšík - Separations, 2021 - mdpi.com
Like many biological compounds, proteins are found primarily in their homochiral form.
However, homochirality is not guaranteed throughout life. Determining their chiral …

[HTML][HTML] Stereoselective separation of dimethenamid by cyclodextrin electrokinetic chromatography using deep eutectic solvents

MÁ García, S Jiménez-Jiménez, ML Marina - Journal of Chromatography A, 2022 - Elsevier
Abstract An Electrokinetic Chromatography (EKC) method was developed in this work
enabling for the first time the separation of the four stereoisomers of the acetamide herbicide …

[HTML][HTML] Effect of ionic liquids and deep eutectic solvents on the enantiomeric separation of clopidogrel by cyclodextrin-electrokinetic chromatography. Quantitative …

L Garcia-Cansino, ML Marina, MÁ García - Microchemical Journal, 2021 - Elsevier
The effect of ionic liquids (ILs) and deep eutectic solvents (DESs) on the chiral separation of
clopidogrel by Cyclodextrin-Electrokinetic Chromatography (CD-EKC) was investigated in …

[HTML][HTML] Enantioseparation and ecotoxicity evaluation of ibrutinib by electrokinetic chromatography using single and dual systems

L García-Cansino, K Boltes, ML Marina, MÁ García - Talanta, 2023 - Elsevier
In this work, two chiral methods enabling the separation of ibrutinib enantiomers were
developed by Electrokinetic Chromatography. A cyclodextrin (CD) or a mixture of the CD …