Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer's Disease

L Wang, Y Zhou, D Chen, TH Lee - Frontiers in cell and …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia with cognitive decline. The
neuropathology of AD is characterized by intracellular aggregation of neurofibrillary tangles …

A novel bacterial l‐arginine sensor controlling c‐di‐GMP levels in Pseudomonas aeruginosa

A Paiardini, F Mantoni, G Giardina… - Proteins: Structure …, 2018 - Wiley Online Library
Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms
in natural environments and in host–pathogen interactions. Beyond taking part to cellular …

Revealing Allosteric Mechanism of Amino Acid Binding Proteins from Open to Closed State

Q Shi, L Liu, H Duan, Y Jiang, W Luo, G Sun, Y Ge… - Molecules, 2023 - mdpi.com
Amino acid binding proteins (AABPs) undergo significant conformational closure in the
periplasmic space of Gram-negative bacteria, tightly binding specific amino acid substrates …

A novel mode of control of nickel uptake by a multifunctional metallochaperone

M Denic, E Turlin, V Michel, F Fischer… - PLoS …, 2021 - journals.plos.org
Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation.
In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence …

Effect of different cloning strategies in pET-28a on solubility and functionality of a staphylococcal phage endolysin

HY Tham, AAL Song, K Yusoff, GH Tan - Biotechniques, 2020 - Taylor & Francis
Endolysins have been studied intensively as an alternative to antibiotics. In this study,
endolysin derived from a phage which infects methicillin-resistant Staphylococcus aureus …

Comparative effects of trifluoromethyl-and methyl-group substitutions in proline

V Kubyshkin, S Pridma, N Budisa - New Journal of Chemistry, 2018 - pubs.rsc.org
Proline is one of a kind. This amino acid exhibits a variety of unique functions in biological
contexts, which continue to be discovered and developed. In addition to the reactivity of the …

Nonenzymatic Posttranslational Modifications and Peptide Cleavages Observed in Peptide Epimers

CC Long, A Antevska, DH Mast, S Okyem… - Journal of the …, 2023 - ACS Publications
Posttranslational modifications (PTMs) play vital roles in cellular homeostasis and are
implicated in various pathological conditions. This work uses two ion mobility spectrometry …

Thermodynamic and kinetic analysis of the LAO binding protein and its isolated domains reveal non‐additivity in stability, folding and function

R Vergara, T Berrocal, EI Juárez Mejía… - The FEBS …, 2023 - Wiley Online Library
Substrate‐binding proteins (SBPs) are used by organisms from the three domains of life for
transport and signalling. SBPs are composed of two domains that collectively trap ligands …

[HTML][HTML] PIN1基因敲除的长白猪胎儿成纤维细胞系的建立

王万义, 袁益琳, 李琳, 王盈, 戴一凡, 杨海元 - 2022 - aammt.tmmu.edu.cn
目的利用成簇的规律间隔短回文重复序列和相关蛋白9 (clustered regular interval short
palindromic repeats/CRISPR-associated protein 9, CRISPR/Cas9) 基因编辑技术敲除长白猪 …

Signalna uloga L-arginina u bakterija

A Madunić - 2024 - repozitorij.pmf.unizg.hr
Sažetak Prijenos signala je ključan stanični proces koji omogućava usklađivanje i
reguliranje metabolizma u svim domenama života. Funkcionira na način da se …