Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

Heart failure is one of the leading causes of death worldwide and has been singled out as
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …

The heart utilizes multiple adaptive mechanisms to maintain pump function. Compensatory
cardiac hypertrophy reduces wall stress and oxygen consumption, thereby protecting the …

The network for cardiac fuel metabolism contains intricate sets of interacting pathways that
result in both ATP-producing and non–ATP-producing end points for each class of energy …

Background: Accumulating evidence suggests that the failing heart reprograms fuel
metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone …

Background: Impairments of mitochondrial function in the heart are linked intricately to the
development of heart failure, but there is no therapy for mitochondrial dysfunction. Methods …

Despite existing therapy, patients with heart failure (HF) experience substantial morbidity
and mortality, highlighting the urgent need to identify novel pathophysiological mechanisms …