Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates
SS Panda, AS Girgis, SJ Thomas, JE Capito… - European Journal of …, 2020 - Elsevier
A series of curcumin bis-conjugates 3a-q, 5a-k and 6a-k were synthesized in good yields
utilizing an optimized reaction condition. We explored the effect of different amino acids and …
utilizing an optimized reaction condition. We explored the effect of different amino acids and …
Novel thiazolidines: Synthesis, antiproliferative properties and 2D-QSAR studies
A series of N-substituted (Z)-2-imino-(5Z)-ylidene thiazolidines/thiazolidin-4-ones were
synthesized and their antiproliferative activities against colon (HCT-116) and breast (MCF7) …
synthesized and their antiproliferative activities against colon (HCT-116) and breast (MCF7) …
Design, synthesis, antimicrobial, and DNA gyrase inhibitory properties of fluoroquinolone–dichloroacetic acid hybrids
A series of new fluoroquinolone conjugates 8a–g and 9a–f were synthesized via
benzotriazole‐mediated synthetic approach with good yield and purity. Some of the …
benzotriazole‐mediated synthetic approach with good yield and purity. Some of the …
Novel thiazolidines of potential anti-proliferation properties against esophageal squamous cell carcinoma via ERK pathway
The discovery of a new class of extracellular-signal-regulated kinase (ERK) inhibitors has
been achieved via developing novel 2-imino-5-arylidene-thiazolidine analogues. A novel …
been achieved via developing novel 2-imino-5-arylidene-thiazolidine analogues. A novel …
Synthesis, computational studies, antimycobacterial and antibacterial properties of pyrazinoic acid–isoniazid hybrid conjugates
Benzotriazole and microwave mediated syntheses led to a new set of hybrid conjugates of
pyrazinoic acid with isoniazid via amino acid linkers in excellent yields with retention of …
pyrazinoic acid with isoniazid via amino acid linkers in excellent yields with retention of …
Novel curcumin inspired antineoplastic 1-sulfonyl-4-piperidones: design, synthesis and molecular modeling studies
Background: Curcumin is a well-known example of plant origin exhibiting promising diverse
biological properties such as, anti-inflammatory and antitumor as well as poor …
biological properties such as, anti-inflammatory and antitumor as well as poor …
Facile synthetic approach towards vasorelaxant active 4-hydroxyquinazoline-4-carboxamides
A Facile synthetic approach is reported towards 4-hydroxyquinazoline-4-carboxamides 13a–
i through ring expansion of 2, 3-dioxoindoline-1-carboxamides 10a–c during secondary …
i through ring expansion of 2, 3-dioxoindoline-1-carboxamides 10a–c during secondary …
Synthesis of novel benzo[6,7]cyclohepta[1,2-b]thieno[3,2-e]pyridines and their bis-analogues linked to different spacers: Approach to a new ring system
MS Mohamed Ahmed, AM Abdelfattah… - Synthetic …, 2023 - Taylor & Francis
The synthesis of benzosuberone-fused heterocyclic derivatives is an increasingly intriguing
subject. The current study reports the synthesis of the new ring system benzo [6, 7] …
subject. The current study reports the synthesis of the new ring system benzo [6, 7] …
Fluoroquinolone-3-carboxamide amino acid conjugates: Synthesis, antibacterial properties and molecular modeling studies
RM Bokhtia, SS Panda, AS Girgis… - Medicinal …, 2021 - ingentaconnect.com
Background: Bacterial infections are considered as one of the major global health threats, so
it is very essential to design and develop new antibacterial agents to overcome the …
it is very essential to design and develop new antibacterial agents to overcome the …
Efficient Synthesis and Computational Studies of Useful Guanylating Agents: 1H‐Benzotriazole‐1‐carboximidamides
A new synthetic protocol for the synthesis of 1H‐benzotriazole‐1‐carboximidamides starting
from aryl amines in presence of acylbenzotriazole has been reported. The versatile …
from aryl amines in presence of acylbenzotriazole has been reported. The versatile …