Cationic lipids have become known as one of the most versatile tools for the delivery of
DNA, RNA and many other therapeutic molecules, and are especially attractive because …

Abstract Initially, the Atherton–Todd (AT) reaction was applied for the synthesis of
phosphoramidates by reacting dialkyl phosphite with a primary amine in the presence of …

Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene
delivery and gene silencing, in which scientists are designing novel cationic and procationic …

Recently, promising strategies of plexes include the complexation of nucleic acids with lipids
(lipoplexes) and different kinds of polymers (polyplexes) for delivery of actives and genetic …

Synthetic vectors for therapeutic nucleic acid delivery are currently competing significantly
with their viral counter parts due to their reduced immunogenicity, large payload capacity …

The study presents the effects of blending a cationic gemini surfactant into cationic lipid
bilayers and its impact on the plasmid DNA compaction and delivery process. Using …

Natural lipid molecules are an essential part of life as they constitute the membrane of cells
and organelle. In most of these cases, the hydrophobicity of natural lipids is contributed by …

Lipopolyplexes formulations resulting from association of nucleic acid, cationic liposomes
and a cationic polymer are attracting formulations for siRNA delivery. Herein, imidazole-and …

Nucleic acid delivery constitutes an emerging therapeutic strategy to cure various human
pathologies. This therapy consists of introducing genetic material into the whole body or …

Twelve new quaternary ammonium sophorolipids with long alkyl chains on the nitrogen
atom were synthesized starting from oleic and petroselinic acid‐based sophorolipids. These …