Fluorogenic probes for disease-relevant enzymes

J Zhang, X Chai, XP He, HJ Kim, J Yoon… - Chemical Society …, 2019 - pubs.rsc.org
Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Autophagy and inflammation in chronic respiratory disease

AC Racanelli, SA Kikkers, AMK Choi, SM Cloonan - Autophagy, 2018 - Taylor & Francis
Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …

Airway remodeling in asthma: what really matters

H Fehrenbach, C Wagner, M Wegmann - Cell and tissue research, 2017 - Springer
Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

Mechanisms and therapeutic strategies for non‐T2 asthma

E Sze, A Bhalla, P Nair - Allergy, 2020 - Wiley Online Library
Non‐T2 asthma is traditionally defined as asthma without features of T2 asthma. The
definition is arbitrary and is generally based on the presence of neutrophils in sputum, or the …

Effects of apigenin on RBL-2H3, RAW264. 7, and HaCaT cells: anti-allergic, anti-inflammatory, and skin-protective activities

CH Park, SY Min, HW Yu, K Kim, S Kim, HJ Lee… - International Journal of …, 2020 - mdpi.com
Apigenin (4′, 5, 7-trihydroxyflavone, flavonoid) is a phenolic compound that is known to
reduce the risk of chronic disease owing to its low toxicity. The first study on apigenin …

The development of allergic inflammation

SJ Galli, M Tsai, AM Piliponsky - Nature, 2008 - nature.com
Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly
25% of people in the developed world. In allergic subjects, persistent or repetitive exposure …

Pathogenesis of asthma

ST Holgate - Clinical & Experimental Allergy, 2008 - Wiley Online Library
While asthma is considered an inflammatory disorder of the conducting airways, it is
becoming increasingly apparent that the disease is heterogeneous with respect to …

[HTML][HTML] Chronic inflammation and asthma

JR Murdoch, CM Lloyd - Mutation Research/Fundamental and Molecular …, 2010 - Elsevier
Allergic asthma is a complex and chronic inflammatory disorder which is associated with
airway hyper-responsiveness and tissue remodelling of the airway structure. Although …

Pathophysiology of allergic inflammation

PJ Barnes - Immunological reviews, 2011 - Wiley Online Library
Allergic inflammation is due to a complex interplay between several inflammatory cells,
including mast cells, basophils, lymphocytes, dendritic cells, eosinophils, and sometimes …

Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells

Z Allakhverdi, MR Comeau, HK Jessup… - The Journal of …, 2007 - rupress.org
Compelling evidence suggests that the epithelial cell–derived cytokine thymic stromal
lymphopoietin (TSLP) may initiate asthma or atopic dermatitis through a dendritic cell …