Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

The combination of chemo-and biocatalysis in one pot (integrated catalysis) is a powerful
approach to develop new routes towards important products under mild and environmentally …

Synthesis planning programs trained on chemical reaction data can design efficient routes
to new molecules of interest, but are limited in their ability to leverage rare chemical …

In the past three decades, in vitro systematic evolution of ligands by exponential enrichment
(SELEX) has yielded many aptamers for translational applications in both research and …

Chemoenzymatic techniques have been applied extensively to pharmaceutical
development, most effectively when routine synthetic methods fail. The regioselective and …

The power of cation-initiated cyclizations of polyenes for the synthesis of polycyclic
terpenoids cannot be overstated. However, a major limitation is the intolerance of many …

Chemoenzymatic asymmetric synthesis of an anabolic-androgenic steroid (+)-boldenone (3)
and its prodrug (+)-boldenone undecylenate (4) was accomplished starting from …

Alkaloids are a group of natural products with interesting pharmacological properties and a
long history of medicinal application. Their complex molecular structures have fascinated …

Intrusion into the C–H chemical space of natural products through the strategic deployment
of C–H functionalization reactions could lead to incredibly new molecular diversities with an …

Uridine diphosphate-dependent glycosyltransferases (UGTs) in plants catalyze O-, C-, S-
and N-glycosylation of diverse substrates to yield a wide variety of glycosides with broad …