Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Apart from high-risk scenarios such as the presence of highly penetrant genetic mutations,
breast screening typically comprises mammography or tomosynthesis strategies defined by …

Background: Breast cancer is considered one of the most common cancers in women
caused by various clinical, lifestyle, social, and economic factors. Machine learning has the …

Polygenic risk scores (PRS) measure genetic disease susceptibility by combining risk effects
across the genome. For coronary artery disease (CAD), type 2 diabetes (T2D), and breast …

Pathogenic genetic variants (formerly called mutations) present in the germline of some
individuals are associated with a clinically relevant increased risk of developing lung cancer …

Since their first appearance in the context of schizophrenia and bipolar disorder in 2009,
polygenic risk scores (PRSs) have been described for a large number of common complex …

Since the first polygenic risk score (PRS) in 2007, research in this area has progressed
significantly. The increasing number of SNPs that have been identified by large scale GWAS …

Genome-wide association studies (GWAS) have identified associations between common
genetic variants, single nucleotide polymorphisms (SNPs) and the risk of developing …

Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an
inflammatory demyelinating disease of the CNS. We developed polygenic risk scores (PRS) …

Importance Multiple polygenic risk scores (PRSs) for breast cancer have been developed
from large research consortia; however, their generalizability to diverse clinical settings is …