Pancreatic beta-cell dysfunction in type 2 diabetes
PP Khin, JH Lee, HS Jun - European Journal of Inflammation, 2023 - journals.sagepub.com
Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a
narrow range. Defects in the function and mass of β-cells play a significant role in the …
narrow range. Defects in the function and mass of β-cells play a significant role in the …
Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors
Cellular entry of SARS-CoV-2 is thought to occur through the binding of viral spike S1
protein to ACE2. The entry process involves priming of the S protein by TMPRSS2 and …
protein to ACE2. The entry process involves priming of the S protein by TMPRSS2 and …
Protoplast Isolation and Shoot Regeneration from Protoplast-Derived Callus of Petunia hybrida Cv. Mirage Rose
Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …
regeneration from protoplasts remains challenging. In this study, we investigated the factors …
Heme Oxygenase-1 (HMOX-1) and inhibitor of differentiation proteins (ID1, ID3) are key response mechanisms against iron-overload in pancreatic β-cells
Iron overload promotes the generation of reactive oxygen species (ROS). Pancreatic β-cells
can counter oxidative stress through multiple anti-oxidant responses. Herein, RNA …
can counter oxidative stress through multiple anti-oxidant responses. Herein, RNA …
The coffee diterpene, kahweol, ameliorates pancreatic β-cell function in streptozotocin (STZ)-treated rat INS-1 cells through NF-kB and p-AKT/Bcl-2 pathways
Kahweol is a diterpene molecule found in coffee that exhibits a wide range of biological
activity, including anti-inflammatory and anticancer properties. However, the impact of …
activity, including anti-inflammatory and anticancer properties. However, the impact of …
GDF15 plays a critical role in insulin secretion in INS-1 cells and human pancreatic islets
MG Mohammad, R Saeed… - Experimental …, 2023 - journals.sagepub.com
Mounting evidence points to a link between growth differentiation factor-15 (GDF15)
expression and the onset and progression of diabetes mellitus. However, the exact role of …
expression and the onset and progression of diabetes mellitus. However, the exact role of …
Fat mass and obesity-associated (FTO) gene is essential for insulin secretion and β-cell function: In vitro studies using INS-1 cells and human pancreatic islets
Aims In this study, we investigated the role of the FTO gene in pancreatic β-cell biology and
its association with type 2 diabetes (T2D). To address this issue, human pancreatic islets …
its association with type 2 diabetes (T2D). To address this issue, human pancreatic islets …
Carnosic acid protects INS-1 β-cells against streptozotocin-induced damage by inhibiting apoptosis and improving insulin secretion and glucose uptake
Carnosic acid (CA), a natural polyphenolic diterpene derived from Rosmarinus officinalis,
has been proven to possess a broad spectrum of medicinal properties. Nevertheless, no …
has been proven to possess a broad spectrum of medicinal properties. Nevertheless, no …
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization
VMS Kjær, V Daugvilaite, TM Stepniewski… - Science …, 2023 - science.org
The chemotactic G protein–coupled receptor GPR183 and its most potent endogenous
oxysterol ligand 7α, 25-dihydroxycholesterol (7α, 25-OHC) are important for immune cell …
oxysterol ligand 7α, 25-dihydroxycholesterol (7α, 25-OHC) are important for immune cell …
Investigating the Impact of IL6 on Insulin Secretion: Evidence from INS-1 Cells, Human Pancreatic Islets, and Serum Analysis
Interleukin-6 (IL6) is a pleiotropic cytokine implicated in metabolic disorders and
inflammation, yet its precise influence on insulin secretion and glucose metabolism remains …
inflammation, yet its precise influence on insulin secretion and glucose metabolism remains …