Tailoring hyaluronic acid hydrogels for biomedical applications

Z Luo, Y Wang, J Li, J Wang, Y Yu… - Advanced Functional …, 2023 - Wiley Online Library
Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent
pharmacological properties and versatile chemical groups for modification. Due to their …

Advances in understanding insect chitin biosynthesis

A Yu, M Beck, H Merzendorfer, Q Yang - Insect Biochemistry and Molecular …, 2024 - Elsevier
Chitin, a natural polymer of N-acetylglucosamine chains, is a principal component of the
apical extracellular matrix in arthropods. Chitin microfibrils serve as structural components of …

Mimicking antioxidases and Hyaluronan synthase: a zwitterionic nanozyme for Photothermal Therapy of Osteoarthritis

P Yu, Y Li, H Sun, H Zhang, H Kang, P Wang… - Advanced …, 2023 - Wiley Online Library
Restoring joint homeostasis is crucial for relieving osteoarthritis (OA). Current strategies are
limited to unilateral efforts in joint lubrication, inhibition of inflammation, free radicals …

Structural and mechanistic insights into fungal β-1, 3-glucan synthase FKS1

X Hu, P Yang, C Chai, J Liu, H Sun, Y Wu, M Zhang… - Nature, 2023 - nature.com
The membrane-integrated synthase FKS is involved in the biosynthesis of β-1, 3-glucan, the
core component of the fungal cell wall,. FKS is the target of widely prescribed antifungal …

Structural basis for directional chitin biosynthesis

W Chen, P Cao, Y Liu, A Yu, D Wang, L Chen… - Nature, 2022 - nature.com
Chitin, the most abundant aminopolysaccharide in nature, is an extracellular polymer
consisting of N-acetylglucosamine (GlcNAc) units. The key reactions of chitin biosynthesis …

Structure, catalysis, chitin transport, and selective inhibition of chitin synthase

DD Chen, ZB Wang, LX Wang, P Zhao, CH Yun… - Nature …, 2023 - nature.com
Chitin is one of the most abundant natural biopolymers and serves as a critical structural
component of extracellular matrices, including fungal cell walls and insect exoskeletons. As …

Tetrahedral framework nucleic acids/hyaluronic acid-methacrylic anhydride hybrid hydrogel with antimicrobial and anti-inflammatory properties for infected wound …

C Qi, Q Sun, D Xiao, M Zhang, S Gao, B Guo… - International Journal of …, 2024 - nature.com
Bacterial resistance and excessive inflammation are common issues that hinder wound
healing. Antimicrobial peptides (AMPs) offer a promising and versatile antibacterial option …

Structure of a fungal 1, 3-β-glucan synthase

CR Zhao, ZL You, DD Chen, J Hang, ZB Wang, M Ji… - Science …, 2023 - science.org
1, 3-β-Glucan serves as the primary component of the fungal cell wall and is produced by 1,
3-β-glucan synthase located in the plasma membrane. This synthase is a molecular target …

Structural basis for heparan sulfate co-polymerase action by the EXT1–2 complex

H Li, D Chapla, RA Amos, A Ramiah… - Nature chemical …, 2023 - nature.com
Heparan sulfate (HS) proteoglycans are extended (-GlcAβ1, 4GlcNAcα1, 4-) n co-polymers
containing decorations of sulfation and epimerization that are linked to cell surface and …

Modification and crosslinking strategies for hyaluronic acid‐based hydrogel biomaterials

Z Luo, Y Wang, Y Xu, J Wang, Y Yu - Smart Medicine, 2023 - Wiley Online Library
Hyaluronic acid (HA) is an attractive extracellular matrix‐derived polymer. The related HA‐
based hydrogels are emerging to be the hotspots in the cutting edge of biomaterials. The …