Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD)
structural domains. During voltage-dependent gating, conformational changes in the two …

The delayed rectifier potassium IKs channel is an important regulator of the duration of the
ventricular action potential. Hundreds of mutations in the genes (KCNQ1 and KCNE1) …

Piezo proteins are transmembrane ion channels which transduce many forms of mechanical
stimuli into electrochemical signals. Their pore, formed by the assembly of three identical …

Kv7 channels tune neuronal and cardiomyocyte excitability. In addition to the channel
membrane domain, they also have a unique intracellular C-terminal (CT) domain, bound …

Gating of voltage-dependent cation channels involves three general molecular processes:
voltage sensor activation, sensor-pore coupling, and pore opening. KCNQ1 is a voltage …

The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …

The KCNQ1 channel (also called Kv7. 1 or KvLQT1) belongs to the superfamily of voltage‐
gated K+ (Kv) channels. KCNQ1 shares several general features with other Kv channels but …

The I Ks current has an established role in cardiac action potential repolarization, and
provides a repolarization reserve at times of stress. The underlying channels are formed …

ABSTRACT KCNQ1 and KCNE1 co-assembly generates the I KS K+ current, which is crucial
to the cardiac action potential repolarization. Mutations in their corresponding genes cause …

Mutations in the SCN8A gene, encoding the voltage-gated sodium channel Na V 1.6, are
associated with a range of neurodevelopmental syndromes. The p.(Gly1625Arg)(G1625R) …