Chemically-induced epileptic seizures in zebrafish: A systematic review

R Chitolina, M Gallas-Lopes, CG Reis, R Benvenutti… - Epilepsy Research, 2023 - Elsevier
The use of zebrafish as a model organism is gaining evidence in the field of epilepsy as it
may help to understand the mechanisms underlying epileptic seizures. As zebrafish assays …

Revealing single-neuron and network-activity interaction by combining high-density microelectrode array and optogenetics

T Kobayashi, K Shimba, T Narumi, T Asahina… - Nature …, 2024 - nature.com
The synchronous activity of neuronal networks is considered crucial for brain function.
However, the interaction between single-neuron activity and network-wide activity remains …

Conditional knockout of ASK1 in microglia/macrophages attenuates epileptic seizures and long-term neurobehavioural comorbidities by modulating the inflammatory …

Y Zhang, Z Wang, R Wang, L Xia, Y Cai, F Tong… - Journal of …, 2022 - Springer
Background Apoptosis signal-regulating kinase 1 (ASK1) not only causes neuronal
programmed cell death via the mitochondrial pathway but also is an essential component of …

Chemo-kindling in adult zebrafish alters spatial cognition but not social novelty recognition

S Kumari, P Dhiman, R Kumar, SN Rahmatkar… - Behavioural Brain …, 2023 - Elsevier
In the past decades, zebrafish have gathered immense attention and importance in the field
of neurological sciences. In the case of epilepsy, zebrafish have appeared as a promising …

Interleukin-4 reduces lesion volume and improves neurological function in the acute phase after experimental traumatic brain injury in mice

J Walter, O Kovalenko, A Younsi, M Grutza… - Journal of …, 2022 - liebertpub.com
Little is known about the impact of interleukin-4 (IL-4) on secondary brain damage in the
acute phase after experimental traumatic brain injury (TBI). Therefore, we evaluated the …

Kindling Models of Epileptogenesis for Developing Disease‐Modifying Drugs for Epilepsy

DS Reddy, A Vadassery, S Ramakrishnan… - Current …, 2024 - Wiley Online Library
Kindling models are widely used animal models to study the pathobiology of epilepsy and
epileptogenesis. These models exhibit distinctive features whereby sub‐threshold stimuli …

Scorpion venom heat-resistant synthesized peptide ameliorates epileptic seizures and imparts neuroprotection in rats mediated by NMDA receptors

AR Sui, H Piao, ST Xiong, P Zhang, SY Guo… - European Journal of …, 2024 - Elsevier
Finding new and effective natural products for designing antiepileptic drugs is highly
important in the scientific community. The scorpion venom heat-resistant peptide (SVHRP) …

Age-Dependent Phenomena of 6-Hz Corneal Kindling Model in Mice

X Yu, H Yang, HJ Lv, H Lu, H Zhao, Z Xu - Molecular Neurobiology, 2024 - Springer
Although numerous studies have acknowledged disparities in epilepsy-related disease
processes between young and aged animals, little is known about how epilepsy changes …

[HTML][HTML] Phagocytic Function Analyses of GABBR-Related Microglia in Immature Developing Epileptic Brain Based on 10× Single-Nucleus RNA Sequencing …

Y Gan, X Yang, T Li, Z Han, L Cheng, L Xie, L Jiang - Biomedicines, 2025 - mdpi.com
Background: Epilepsy is a neurological disorder defined by the occurrence of epileptic
seizures, which can significantly affect children, often leading to learning and cognitive …

Magnesium-L-threonate treats Alzheimer's disease by modulating the microbiota-gut-brain axis

W Liao, J Wei, C Liu, H Luo, Y Ruan… - Neural Regeneration …, 2024 - journals.lww.com
Disturbances in the microbiota-gut-brain axis may contribute to the development of
Alzheimer's disease. Magnesium-L-threonate has recently been found to have protective …