Lizard tail regeneration as an instructive model of enhanced healing capabilities in an adult amniote

TP Lozito, RS Tuan - Connective tissue research, 2017 - Taylor & Francis
The ability to regenerate damaged or lost tissues has remained the lofty goal of regenerative
medicine. Unfortunately, humans, like most mammals, suffer from very minimal natural …

The anatomy and histology of caudal autotomy and regeneration in lizards

EAB Gilbert, SL Payne… - Physiological and …, 2013 - journals.uchicago.edu
Caudal autotomy—the ability to self-detach the tail—is a dramatic adaptation common to
many structural-grade lizards. For most species, tail loss is followed by the equally dramatic …

Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis

AC Vonk, X Zhao, Z Pan, ML Hudnall… - Nature …, 2023 - nature.com
Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …

Transcriptomic Analysis of Tail Regeneration in the Lizard Anolis carolinensis Reveals Activation of Conserved Vertebrate Developmental and Repair Mechanisms

ED Hutchins, GJ Markov, WL Eckalbar, RM George… - PloS one, 2014 - journals.plos.org
Lizards, which are amniote vertebrates like humans, are able to lose and regenerate a
functional tail. Understanding the molecular basis of this process would advance …

Histochemical, biochemical and cell biological aspects of tail regeneration in lizard, an amniote model for studies on tissue regeneration

L Alibardi - Progress in Histochemistry and Cytochemistry, 2014 - Elsevier
The present review summarizes biochemical, histochemical and immunocytochemical
aspects of the process of tissue regeneration in lizards, non-mammalian amniotes with high …

Appendage regeneration in vertebrates: what makes this possible?

V Daponte, P Tylzanowski, A Forlino - Cells, 2021 - mdpi.com
The ability to regenerate amputated or injured tissues and organs is a fascinating property
shared by several invertebrates and, interestingly, some vertebrates. The mechanism of …

Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration

TP Lozito, RS Tuan - Development, 2016 - journals.biologists.com
Lizards are amniotes with the remarkable ability to regenerate amputated tails. The early
regenerated lizard tail forms a blastema, and the regenerated skeleton consists of a …

Appendage regeneration in anamniotes utilizes genes active during larval‐metamorphic stages that have been lost or altered in amniotes: the case for studying lizard …

L Alibardi - Journal of morphology, 2020 - Wiley Online Library
This review elaborates the idea that organ regeneration derives from specific evolutionary
histories of vertebrates. Regenerative ability depends on genomic regulation of genes …

[HTML][HTML] Lizard tail regeneration: regulation of two distinct cartilage regions by Indian hedgehog

TP Lozito, RS Tuan - Developmental Biology, 2015 - Elsevier
Lizards capable of caudal autotomy exhibit the remarkable ability to “drop” and then
regenerate their tails. However, the regenerated lizard tail (RLT) is known as an “imperfect …

Deep-time evolution of regeneration and preaxial polarity in tetrapod limb development

NB Fröbisch, C Bickelmann, JC Olori, F Witzmann - Nature, 2015 - nature.com
Among extant tetrapods, salamanders are unique in showing a reversed preaxial polarity in
patterning of the skeletal elements of the limbs, and in displaying the highest capacity for …