Arrayed CRISPRi and quantitative imaging describe the morphotypic landscape of essential mycobacterial genes

TJ de Wet, KR Winkler, M Mhlanga, V Mizrahi… - Elife, 2020 - elifesciences.org
Mycobacterium tuberculosis possesses a large number of genes of unknown or predicted
function, undermining fundamental understanding of pathogenicity and drug susceptibility …

De novo histidine biosynthesis protects Mycobacterium tuberculosis from host IFN-γ mediated histidine starvation

A Dwivedy, A Ashraf, B Jha, D Kumar… - Communications …, 2021 - nature.com
Intracellular pathogens including Mycobacterium tuberculosis (Mtb) have evolved with
strategies to uptake amino acids from host cells to fulfil their metabolic requirements …

Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery

M Guida, C Tammaro, M Quaranta, B Salvucci, M Biava… - Pharmaceutics, 2024 - mdpi.com
According to the latest World Health Organization (WHO) report, an estimated 10.6 million
people were diagnosed with tuberculosis (TB) in 2022, and 1.30 million died. A major …

Characterization of a Novel Antimicrobial Peptide Bacipeptin against Foodborne Pathogens

X Wei, Y Hu, C Sun, S Wu - Journal of Agricultural and Food …, 2024 - ACS Publications
The increasing emergence of multidrug-resistant pathogens and development of
biopreservatives in food industries has increased the demand of novel and safe …

Supplementation of lactobacillus‐fermented rapeseed meal in broiler diet reduces Campylobacter jejuni cecal colonization and limits the l‐tryptophan and l …

F Khattak, S Galgano, NR Pedersen… - Journal of the …, 2024 - Wiley Online Library
BACKGROUND Campylobacter jejuni (C. jejuni), a widely distributed global foodborne
pathogen, primarily linked with contaminated chicken meat, poses a significant health risk …

Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis imidazoleglycerol‐phosphate dehydratase

D Kumar, B Jha, I Bhatia, A Ashraf… - Proteins: Structure …, 2022 - Wiley Online Library
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), employs
ten enzymes including imidazoleglycerol‐phosphate dehydratase (IGPD) for de novo …

A whole genome bioinformatic approach to determine potential latent phase specific targets in Mycobacterium tuberculosis

LA Defelipe, DF Do Porto, PIP Ramos, MF Nicolás… - Tuberculosis, 2016 - Elsevier
Current Tuberculosis treatment is long and expensive, faces the increasing burden of
MDR/XDR strains and lack of effective treatment against latent form, resulting in an urgent …

Rv2231c, a unique histidinol phosphate aminotransferase from Mycobacterium tuberculosis, supports virulence by inhibiting host-directed defense

S Zarin, M Shariq, N Rastogi, Y Ahuja… - Cellular and Molecular …, 2024 - Springer
Nitrogen metabolism of M. tuberculosis is critical for its survival in infected host cells. M.
tuberculosis has evolved sophisticated strategies to switch between de novo synthesis and …

[HTML][HTML] Interaction of antitubercular drug candidates with α1-acid glycoprotein produced in pulmonary granulomas

F Zsila, S Bősze, T Beke-Somfai - International journal of biological …, 2020 - Elsevier
The intracellular pathogen Mycobacterium tuberculosis can survive and replicate within host
macrophages. Among various immunomodulatory substances, macrophages also produce …

Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials

CA Rice, SJ Campbell, C Bisson, HJ Owen… - PLoS …, 2018 - journals.plos.org
Acanthamoeba is normally free-living, but sometimes facultative and occasionally
opportunistic parasites. Current therapies are, by necessity, arduous and yet poorly effective …