The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes

P Krzyszczyk, R Schloss, A Palmer… - Frontiers in …, 2018 - frontiersin.org
Macrophages play key roles in all phases of adult wound healing, which are inflammation,
proliferation, and remodeling. As wounds heal, the local macrophage population transitions …

From pathogenesis of acne vulgaris to anti-acne agents

TX Cong, D Hao, X Wen, XH Li, G He… - Archives of dermatological …, 2019 - Springer
Acne vulgaris is a cutaneous chronic inflammatory disorder with complex pathogenesis.
Four factors play vital roles in acne pathophysiology: hyperseborrhea and dysseborrhea …

TREM2 macrophages induced by human lipids drive inflammation in acne lesions

TH Do, F Ma, PR Andrade, R Teles… - Science …, 2022 - science.org
Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …

Cutaneous barriers and skin immunity: differentiating a connected network

S Eyerich, K Eyerich, C Traidl-Hoffmann… - Trends in …, 2018 - cell.com
The skin is the outermost barrier of the organism that ensures protection from external harm.
Lately, our view of the skin has evolved from an inert mechanical barrier to an active organ …

Sebaceous immunobiology-skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations

CC Zouboulis, T Coenye, L He, K Kabashima… - Frontiers in …, 2022 - frontiersin.org
This review presents several aspects of the innovative concept of sebaceous
immunobiology, which summarizes the numerous activities of the sebaceous gland …

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

R Choa, J Tohyama, S Wada, H Meng, J Hu… - Science, 2021 - science.org
INTRODUCTION Obesity and its associated complications are serious global concerns.
Despite growing public health initiatives, obesity rates continue to rise. Thus, there is a …

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis

RW Clayton, K Göbel, CM Niessen… - British Journal of …, 2019 - academic.oup.com
Summary Background Sebaceous glands (SGs) are appendages of mammalian skin that
produce a mixture of lipids known as sebum. Acne vulgaris is an exceptionally common skin …

Current insights into the biological action of squalene

JM Lou‐Bonafonte… - Molecular nutrition & …, 2018 - Wiley Online Library
Squalene is a triterpenic compound found in a large number of plants and other sources
with a long tradition of research since it was first reported in 1926. Herein a systematic …

Sebaceous-immunobiology is orchestrated by sebum lipids

M Lovászi, A Szegedi, CC Zouboulis… - Dermato …, 2017 - Taylor & Francis
The major role of sebaceous glands in mammals is to produce sebum, which coats the
epidermis and the hair providing waterproofing, thermoregulation and photoprotection …

Role of the microbiome in oral cancer occurrence, progression and therapy

Z Li, Y Liu, L Zhang - Microbial Pathogenesis, 2022 - Elsevier
The oral cavity, like other digestive or mucosal sites, contains a site-specific microbiome that
plays a significant role in maintaining health and homeostasis. Strictly speaking, the …