During early development, the hindbrain is sub-divided into rhombomeres that underlie the
organisation of neurons and adjacent craniofacial tissues. A gene regulatory network of …

Hox genes play key roles in axial patterning and regulating the regional identity of cells and
tissues in a wide variety of animals from invertebrates to vertebrates. Nested domains of Hox …

Hox genes code for transcription factors and are evolutionarily conserved. They regulate a
plethora of downstream targets to define the anterior-posterior (AP) body axis of a …

Metazoans differentially express multiple Hox transcription factors to specify diverse cell
fates along the developing anterior-posterior axis. Two challenges arise when trying to …

Objective. Recent studies have demonstrated that homeobox A1 (HOXA1) is upregulated in
lung cancer due to RNA modifications (N6‐methyladenosine), but the specific function of …

Gene duplication and divergence is a major contributor to the generation of morphological
diversity and the emergence of novel features in vertebrates during evolution. The …

During evolution, bilateral animals have experienced a progressive process of cephalization
with the anterior concentration of nervous tissue, sensory organs and the appearance of …

Mites, the second largest arthropod group, exhibit rich phenotypic diversity in the
development of appendages (legs). For example, the fourth pair of legs (L4) does not form …

Homeotic genes (Hox genes) are homeodomain-transcription factors involved in conferring
segmental identity along the anterior-posterior body axis. Molecular characterization of HOX …

Knowledge of the diverse DNA binding specificities of transcription factors is important for
understanding their specific regulatory functions in animal development and evolution. We …