Current challenges in vaccinology

RB Kennedy, IG Ovsyannikova, P Palese… - Frontiers in …, 2020 - frontiersin.org
The development of vaccines, which prime the immune system to respond to future
infections, has led to global declines in morbidity and mortality from dreadful infectious …

Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century

GA Poland, RB Kennedy, BA McKinney… - Seminars in …, 2013 - Elsevier
Vaccines, like drugs and medical procedures, are increasingly amenable to individualization
or personalization, often based on novel data resulting from high throughput “omics” …

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

CA Rietveld, SE Medland, J Derringer, J Yang, T Esko… - science, 2013 - science.org
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Will host genetics affect the response to SARS-CoV-2 vaccines? Historical precedents

MK Smatti, HA Alkhatib, AA Al Thani… - Frontiers in …, 2022 - frontiersin.org
Recent progress in genomics and bioinformatics technologies have allowed for the
emergence of immunogenomics field. This intersection of immunology and genetics has …

Immune response stability to the SARS-CoV-2 mRNA vaccine booster is influenced by differential splicing of HLA genes

CB Santos-Rebouças, CS Ferreira, JS Nogueira… - Scientific Reports, 2024 - nature.com
Many molecular mechanisms that lead to the host antibody response to COVID-19 vaccines
remain largely unknown. In this study, we used serum antibody detection combined with …

Age and cytokine gene variants modulate the immunogenicity and protective effect of SARS-CoV-2 mrna-based vaccination

L Scola, D Ferraro, GL Sanfilippo, S De Grazia, D Lio… - Vaccines, 2023 - mdpi.com
The introduction of anti-SARS-CoV-2 vaccines in late 2020 substantially changed the
pandemic picture, inducing effective protection in the population. However, individual …

Bacillus anthracis and other Bacillus species

CK Cote, JD Heffron, SO Bailey, SL Welkos… - Molecular medical …, 2024 - Elsevier
The genus Bacillus is a diverse group of spore-forming bacteria. Bacillus species have
implications in both medical and biodefense aspects of microbiology. This chapter attempts …

Human leukocyte antigens and cellular immune responses to anthrax vaccine adsorbed

IG Ovsyannikova, VS Pankratz, RA Vierkant… - Infection and …, 2013 - Am Soc Microbiol
Interindividual variations in vaccine-induced immune responses are in part due to host
genetic polymorphisms in the human leukocyte antigen (HLA) and other gene families. This …

Influence of genetics and the pre-vaccination blood transcriptome on the variability of antibody levels after vaccination against Mycoplasma hyopneumoniae in pigs

F Blanc, T Maroilley, M Revilla, G Lemonnier… - Genetics Selection …, 2021 - Springer
Background The impact of individual genetic and genomic variations on immune responses
is an emerging lever investigated in vaccination strategies. In our study, we used genetic …

The genetic regulation of infant immune responses to vaccination

MJ Newport - Frontiers in immunology, 2015 - frontiersin.org
A number of factors are recognized to influence immune responses to vaccinations including
age, gender, the dose, and quality of the antigen used, the number of doses given, the route …