Self-assembly of misfolded proteins into ordered fibrillar aggregates known as amyloid
results in various human diseases. However, more and more proteins, whether in human …

Insulin is a therapeutically relevant molecule with use in treating diabetes patients.
Unfortunately, it undergoes a range of untoward and often unpredictable physical …

The amount of unfolded proteins is increased in cancer cells, leading to endoplasmic
reticulum (ER) stress. Therefore, cancer cells are sensitive to drugs capable of further …

Globally, millions of diabetic patients require daily life-saving insulin injections. Insulin heat-
lability and fibrillation pose significant challenges, especially in parts of the world without …

Neurodegenerative diseases are often associated with an uncontrolled amyloid
aggregation. Hence, many studies are oriented to discover new compounds that are able to …

Amyloid aggregation is at the molecular basis of neurodegeneration and provides toxic
species which trigger the progression of the disease. Hence, there is an urgent need to …

The discovery of insulin came with very high hopes for diabetic patients. In 2021, the world
celebrated the 100th anniversary of the discovery of this vital hormone. However, external …

An ability of the ribbed-functionalized iron (II) clathrochelates to induce a CD output in
interactions with a protein, covalent bonding or supramolecular interactions with a low …

An ability of inherently achiral macrobicyclic metal complexes iron (ii) clathrochelates to
acquire an induced CD (ICD) output in the visible spectral range upon interaction with …

Cage metal complexes iron (II) clathrochelates, which are inherently CD silent, were
discovered to demonstrate intensive output in induced circular dichroism (ICD) spectra upon …