DNA polymerases were named for their function of catalysing DNA replication, a process
that is necessary for growth and propagation of life. DNA involving Watson–Crick base …

DNA and RNA polymerases (Pols) are central to life, health, and biotechnology because
they allow the flow of genetic information in biological systems. Importantly, Pol function and …

Metal-dependent DNA and RNA nucleases are enzymes that cleave nucleic acids with great
efficiency and precision. These enzyme-mediated hydrolytic reactions are fundamental for …

Elucidating the nature of the gene editing mechanism of CRISPR (Clustered Regularly
Interspaced Short Palindromic Repeats) is an important task in view of the role of this …

Abstract The phosphoryl group, PO 3–, is the dynamic structural unit in the biological
chemistry of phosphorus. Its transfer from a donor to an acceptor atom, with oxygen much …

E1cB and E2 eliminations have been described as competing mechanisms that can even
share a common pathway when the E1cB/E2 borderline mechanism operates. A suitable …

Abstract The oxidized nucleotide, 8-oxo-7, 8-dihydro-2΄-deoxyguanosine (8-oxoG), is one of
the most abundant DNA lesions. 8-oxoG plays a major role in tumorigenesis and human …

In this work we report a computational study about the aza-SNAr mechanism in fluorine-and
chlorine-containing azines with the aim to unravel the physical factors that determine the …

DNA replication is a fundamental process for life. Despite previous experimental and
computational studies of the reaction pathway catalyzed by a variety of DNA polymerases …

DNA polymerases (Pols) play important roles in the transmission of genetic information.
Although the function and (de) regulation of Pols are linked to many human diseases, the …