Abstract Background and Aims The epidemic of obesity is associated with a substantial,
complex and escalating burden of disease. Dietary and lifestyle interventions provide the …

Simple Summary In mammals, many physiological processes follow a 24 h rhythmic pattern.
These rhythms are governed by a complex network of circadian clocks, which perceives …

The cell biology of circadian clocks is still in its infancy. Here, we describe an efficient
strategy for generating knock-in reporter cell lines using CRISPR technology that is …

Transcriptional repression can occur via various mechanisms, such as blocking,
sequestration and displacement. For instance, the repressors can hold the activators to …

Currently, there is no pharmacological treatment targeting defective tissue repair in chronic
disease. Here, we used a transcriptomics-guided drug target discovery strategy using gene …

Oscillations of the cellular circadian clock have emerged as an important regulator of many
physiological processes, both in health and in disease. One such process, cellular …

Background and aims The rising prevalence of obesity is a major international concern and
is associated with a substantial burden of disease. Disrupted circadian behaviours …

We present a comprehensive dynamical analysis of a chaotic chemical model referred to as
the autocatalator, when subject to a periodic administration of one substrate. Our …

The cell cycle and the circadian clock are essential cyclic cellular processes often
synchronous in healthy cells. In this work, we use previously developed mathematical …

The intercellular interactions between peripheral circadian clocks, located in tissues and
organs other than the suprachiasmatic nuclei of the hypothalamus, are still very poorly …