Reticulated platelets: analytical aspects and clinical utility

JJML Hoffmann - Clinical Chemistry and Laboratory Medicine (CCLM …, 2014 - degruyter.com
Reticulated platelets are immature platelets circulating in blood; they reflect the activity of
megakaryopoiesis in the bone marrow. Therefore, they can be used as a non-invasive test in …

Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta‐analysis

F Zaccardi, B Rocca, D Pitocco… - Diabetes/metabolism …, 2015 - Wiley Online Library
Background Platelet activation contributes to cardiovascular disease (CVD), the main
complication of type 2 diabetes mellitus (T2DM) and pre‐diabetic conditions. Mean platelet …

Association of immature platelets with adverse cardiovascular outcomes

H Ibrahim, RC Schutt, B Hannawi, T DeLao… - Journal of the American …, 2014 - jacc.org
Background: Immature platelets are less responsive to the effects of antiplatelet drugs and
contain messenger ribonucleic acid that is translationally active. They can be measured …

Transcriptome analysis of reticulated platelets reveals a prothrombotic profile

D Bongiovanni, G Santamaria, M Klug… - Thrombosis and …, 2019 - thieme-connect.com
Reticulated platelets (RPs) are larger, hyperreactive platelets that contain significantly more
ribonucleic acid (RNA) compared with mature platelets (MPs). High levels of RPs in …

Impact of immature platelets on platelet response to ticagrelor and prasugrel in patients with acute coronary syndrome

I Bernlochner, A Goedel, C Plischke… - European heart …, 2015 - academic.oup.com
Aims The influence of reticulated platelets (RPs) on platelet inhibition by ticagrelor when
compared with prasugrel is unknown. We aimed to determine the influence of RPs on …

Immature platelets as a biomarker for disease severity and mortality in COVID‐19 patients

D Welder, H Jeon‐Slaughter, B Ashraf… - British Journal of …, 2021 - Wiley Online Library
Summary COVID‐19, caused by SARS‐CoV‐2, is a contagious life‐threatening viral
disease that has killed more than three million people worldwide to date. Attempts have …

Newly formed reticulated platelets undermine pharmacokinetically short-lived antiplatelet therapies

PC Armstrong, T Hoefer, RB Knowles… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Aspirin together with thienopyridine P2Y12 inhibitors, commonly clopidogrel, is a
cornerstone of antiplatelet therapy. However, many patients receiving this therapy display …

[HTML][HTML] Ultrastructural, transcriptional, and functional differences between human reticulated and non‐reticulated platelets

L Hille, M Lenz, A Vlachos, B Grüning, L Hein… - Journal of Thrombosis …, 2020 - Elsevier
Background Reticulated platelets (RP) are the youngest circulating platelets in blood. An
increased amount of this subpopulation is associated with higher cardiovascular risk and …

Role of reticulated platelets in cardiovascular disease

D Bongiovanni, J Han, M Klug, K Kirmes… - … and Vascular Biology, 2022 - Am Heart Assoc
Human platelets differ considerably with regard to their size, RNA content and
thrombogenicity. Reticulated platelets (RPs) are young, hyper-reactive platelets that are …

Comparison of immature platelet count to established predictors of platelet reactivity during thienopyridine therapy

C Stratz, T Bömicke, I Younas, A Kittel, M Amann… - Journal of the American …, 2016 - jacc.org
Background: Previous data suggest that reticulated platelets significantly affect antiplatelet
response to thienopyridines. It is unknown whether parameters describing reticulated …